Document Detail

Food-anticipatory activity and liver per1-luc activity in diabetic transgenic rats.
MedLine Citation:
PMID:  12175585     Owner:  NLM     Status:  MEDLINE    
The mammalian Per1 gene is an important component of the core cellular clock mechanism responsible for circadian rhythms. The rodent liver and other tissues rhythmically express Per1 in vitro but typically damp out within a few cycles. In the liver, the peak of this rhythm occurs in the late subjective night in an ad lib-fed rat, but will show a large phase advance in response to restricted availability of food during the day. The relationship between this shift in the liver clock and food-anticipatory activity (FAA), the circadian behavior entrained by daily feeding, is currently unknown. Insulin is released during feeding in mammals and could serve as an entraining signal to the liver. To test the role of insulin in the shift in liver Per1 expression and the generation of FAA, per-luciferase transgenic rats were made diabetic with a single injection of streptozotocine. Following 1 week of restricted feeding and locomotor activity monitoring, liver was collected for per-luc recording. In two separate experiments, FAA emerged and liver Per1 phase-shifted in response to daytime 8-h food restriction. The results rule out insulin as a necessary component of this system.
Alec J Davidson; Karl-Arne Stokkan; Shin Yamazaki; Michael Menaker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  76     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-08-14     Completed Date:  2003-01-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM; S    
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
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MeSH Terms
Animals, Genetically Modified
Blood Glucose / metabolism
Cell Cycle Proteins
Circadian Rhythm / genetics,  physiology
Culture Techniques
Diabetes Mellitus, Experimental / genetics,  psychology*
Feeding Behavior / physiology*
Food Deprivation / physiology
Liver / metabolism*
Luciferases / genetics*
Motor Activity / physiology
Nuclear Proteins / genetics*
Period Circadian Proteins
Promoter Regions, Genetic / genetics
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Cell Cycle Proteins; 0/Nuclear Proteins; 0/PER1 protein, human; 0/Per1 protein, rat; 0/Period Circadian Proteins; EC 1.13.12.-/Luciferases
M Menaker / U VA, Charlottesville

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