| Food-anticipatory activity and liver per1-luc activity in diabetic transgenic rats. | |
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MedLine Citation:
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PMID: 12175585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mammalian Per1 gene is an important component of the core cellular clock mechanism responsible for circadian rhythms. The rodent liver and other tissues rhythmically express Per1 in vitro but typically damp out within a few cycles. In the liver, the peak of this rhythm occurs in the late subjective night in an ad lib-fed rat, but will show a large phase advance in response to restricted availability of food during the day. The relationship between this shift in the liver clock and food-anticipatory activity (FAA), the circadian behavior entrained by daily feeding, is currently unknown. Insulin is released during feeding in mammals and could serve as an entraining signal to the liver. To test the role of insulin in the shift in liver Per1 expression and the generation of FAA, per-luciferase transgenic rats were made diabetic with a single injection of streptozotocine. Following 1 week of restricted feeding and locomotor activity monitoring, liver was collected for per-luc recording. In two separate experiments, FAA emerged and liver Per1 phase-shifted in response to daytime 8-h food restriction. The results rule out insulin as a necessary component of this system. |
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Authors:
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Alec J Davidson; Karl-Arne Stokkan; Shin Yamazaki; Michael Menaker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 76 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-08-14 Completed Date: 2003-01-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM; S |
Affiliation:
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Department of Biology, University of Virginia, Charlottesville, VA 22904, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Blood Glucose / metabolism Cell Cycle Proteins Circadian Rhythm / genetics, physiology Culture Techniques Diabetes Mellitus, Experimental / genetics, psychology* Feeding Behavior / physiology* Female Food Deprivation / physiology Liver / metabolism* Luciferases / genetics* Motor Activity / physiology Nuclear Proteins / genetics* Period Circadian Proteins Promoter Regions, Genetic / genetics Rats |
| Grant Support | |
ID/Acronym/Agency:
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MH 56647/MH/NIMH NIH HHS; T32 DK 07646-10/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cell Cycle Proteins; 0/Nuclear Proteins; 0/PER1 protein, human; 0/Per1 protein, rat; 0/Period Circadian Proteins; EC 1.13.12.-/Luciferases |
| Investigator | |
Investigator/Affiliation:
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M Menaker / U VA, Charlottesville |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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