Document Detail

Food anaphylaxis.
MedLine Citation:
PMID:  11359629     Owner:  NLM     Status:  MEDLINE    
Food anaphylaxis is now the leading single cause of anaphylactic reactions treated in emergency departments in Westernized countries. In the US, it is estimated that there are 29,000 anaphylactic reactions to foods treated in emergency departments and 125-150 deaths each year. Peanuts, tree nuts, fish and shellfish account for the vast majority of severe food anaphylactic reactions. Immunopathogenic mechanisms responsible for food anaphylaxis may differ somewhat from other forms of anaphylaxis, since elevation of serum tryptase is rarely seen following food anaphylactic reactions. Education regarding the strict avoidance of food allergens, the early recognition of anaphylactic symptoms, and the early use of self-injectable epinephrine remain the mainstays of therapy. However, clinical trials are now underway for the treatment of patients with peanut anaphylaxis utilizing anti-IgE antibody therapy and novel immunomodulatory therapies utilizing 'engineered' recombinant proteins, overlapping peptides, and immunostimulatory deoxyoligonucleotide sequences are being tested in animal models of anaphylaxis.
H A Sampson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British medical bulletin     Volume:  56     ISSN:  0007-1420     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  2000  
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-05-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  925-35     Citation Subset:  IM    
Department of Pediatrics, Box 1198, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029-6574, USA.
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MeSH Terms
Acute Disease
Allergens / immunology
Arachis hypogaea / adverse effects
Bronchodilator Agents / therapeutic use
Child, Preschool
Epinephrine / therapeutic use
Food Hypersensitivity / diagnosis,  drug therapy,  immunology*
Histamine H1 Antagonists / therapeutic use
Nuts / adverse effects
Recombinant Proteins / therapeutic use
Shellfish / adverse effects
Time Factors
Reg. No./Substance:
0/Allergens; 0/Bronchodilator Agents; 0/Histamine H1 Antagonists; 0/Recombinant Proteins; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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