| Food allergy, oral tolerance and immunomodulation--their molecular and cellular mechanisms. | |
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MedLine Citation:
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PMID: 8987849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper describes the molecular and cellular mechanisms of food allergy and oral tolerance including immunomodulation. Food allergy is triggered by an aberrant immune response elicited by oral administration of dietary antigens. Oral tolerance is a state of immunological unresponsiveness induced by oral administration of dietary antigens and is thought to serve to suppress food allergy. This review first describes the characteristic properties of T and B cells relating to milk allergy and also the location of binding sites to T and B cells on allergen molecules. The immunogenicity of allergens is shown to be reduced by the modulations of the T cell binding site, using sophisticated methods such as site-specific mutagenesis. Furthermore, this review focuses on oral tolerance with special reference to the identification of lymphocyte compartment subsets and the immunological mechanism relating to oral tolerance. Finally, the application of oral tolerance for the treatment of allergy is speculated on. |
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Authors:
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S Kaminogawa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 60 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-02-24 Completed Date: 1997-02-24 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1749-56 Citation Subset: IM |
Affiliation:
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Department of Applied Biological Chemistry, University of Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / immunology Food Analysis Humans Milk Hypersensitivity / immunology*, physiopathology T-Lymphocytes / immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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