Document Detail

Food allergy: the major cause of infantile colitis.
MedLine Citation:
PMID:  6721558     Owner:  NLM     Status:  MEDLINE    
Forty six children presented with colitis between 1977 and 1981, and all 8 of those below the age of 2 years had food allergic colitis which resolved completely after exclusion of certain foods. In most of the 8 the onset was soon after starting foods other than breast milk. The most common offending food was cows' milk protein, but soya (3 cases) and beef (1 case) were also implicated. A history of allergy in the child or family was common as were blood eosinophilia, high concentrations of serum IgE, and positive IgE antibodies. Colonoscopic appearances were distinctive and biopsies showed a noticeable increase in eosinophils and IgE-containing cells in the lamina propria. We suggest that food allergy is the major cause of colitis in infancy and that an exclusion diet is the treatment of choice.
H R Jenkins; J R Pincott; J F Soothill; P J Milla; J T Harries
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  59     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-05     Completed Date:  1984-06-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Colitis / pathology
Colitis, Ulcerative / etiology*
Crohn Disease / etiology*
Food Hypersensitivity*
Immunoglobulin E / analysis
Infant Food / adverse effects*
Intestinal Mucosa / pathology
Leukocyte Count
Milk / adverse effects
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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