Document Detail

Food allergy and intolerance: response to intestinal provocation monitored by endosonography.
MedLine Citation:
PMID:  12044850     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Objective assessment of adverse reactions to food is a long-felt want. We report our preliminary experience with a new endosonographic allergen provocation test. METHODS: Twenty patients were examined, seven patients having food allergy and 13 having food intolerance. The duodenal mucosa was challenged with allergen extracts via a nasoduodenal tube. The responses were recorded using a miniprobe for endosonography through the tube. Thereafter, intestinal lavage was performed by giving 2 l PEG solution containing micro Ci (51)CrEDTA. The gut lavage fluid and urine for 5 h were collected. RESULTS: Increased mucosal thickness in response to provocation was recorded in 11 patients, but not more often or pronounced in the allergic than in the intolerance group. Interestingly, increased mucosal thickness associated with a new echogenic layer was seen in two patients and a sustained duodenal contraction, lasting 15-20 min associated with pain, in another two. Intestinal permeability and inflammatory mediators were not significantly different in the two groups. CONCLUSION: In patients with self-reported adverse reactions to food abnormal responses to duodenal provocation may be recognised by endosonography. However, neither endosonography nor intestinal permeability or faecal calprotectin responses were able to distinguish between food allergy and intolerance. Sustained duodenal contractions in response to food might be a cause of abdominal pain.
Gülen Arslan; Svein Ødegaard; Said Elsayed; Erik Florvaag; Arnold Berstad
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology     Volume:  15     ISSN:  0929-8266     ISO Abbreviation:  Eur J Ultrasound     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-04     Completed Date:  2002-07-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9440414     Medline TA:  Eur J Ultrasound     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
gulen.Medical Department, Division of Gastroenterology, Institute of Medicine, Haukeland University Hospital, University of Bergen, N-5021, Bergen, Norway.
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MeSH Terms
Allergens / diagnostic use*
Duodenum / immunology,  ultrasonography
Food Hypersensitivity / ultrasonography*
Foodborne Diseases / ultrasonography*
Intestinal Mucosa / immunology,  ultrasonography
Skin Tests
Reg. No./Substance:

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