Document Detail

Food allergy and eosinophilic esophagitis.
MedLine Citation:
PMID:  20410819     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Eosinophilic esophagitis (EoE) is a chronic allergic disease of the esophagus. A mix of immediate, IgE-mediated and delayed, non-IgE-mediated immunological reactions to foods is thought to play a role in EoE. Our purpose is to review available clinical and research evidence for this link between food allergy and EoE. RECENT FINDINGS: Various food elimination trials resulted in various rates of disease remission. Exclusive amino acid formula-based dietary trials resulted in more than 90% remission in children with EoE. Empiric elimination diets consisting of avoidance of foods commonly known to cause hypersensitivity reactions resulted in 50-74% disease remission. When diets were tailored based on results from skin prick and atopy patch tests, remission rates were comparable. Translational research studies performed on esophageal tissues and peripheral blood of patients with EoE demonstrated an allergic T-helper type 2 phenotype, though mechanisms linking the disease to food allergens are not fully addressed. SUMMARY: Foods appear to be important allergic triggers in EoE. Identification of these triggers, however, remains a challenge. Research is needed to elucidate at which point in the pathogenesis of EoE foods become important so that their role can be better understood, and develop better tests to identify these foods.
Mirna Chehade; Seema S Aceves
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
Division of Allergy/immunology, Department of Pediatrics, Mount Sinai Center for Eosinophilic Disorders, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Allergens / administration & dosage,  adverse effects,  immunology
Dietary Proteins / administration & dosage,  adverse effects,  immunology
Esophagitis / diet therapy,  etiology*,  immunology
Food Hypersensitivity / complications*,  diet therapy,  immunology
Food, Formulated
Immunoglobulin E / immunology*
Th2 Cells / immunology*
Grant Support
Reg. No./Substance:
0/Allergens; 0/Dietary Proteins; 37341-29-0/Immunoglobulin E

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