Document Detail

Food allergy and atopic eczema.
MedLine Citation:
PMID:  20375880     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To review recent developments on the inter-relationship between food allergy and atopic eczema, with a particular focus on understanding the role of filaggrin gene defects. RECENT FINDINGS: Filaggrin gene defects have recently been identified as a major risk factor for the development of atopic eczema. These skin barrier defects increase the risk of early onset, severe and persistent forms of atopic eczema. They also increase the risk of allergic sensitization, and asthma and allergic rhinitis in those with co-existent eczema. These skin barrier defects are also likely to increase the risk of food allergy. SUMMARY: Atopic dermatitis and food allergy are frequently herald conditions for other manifestations of 'the allergic march'. They commonly co-exist, particularly in those with early onset, severe and persistent atopic eczema. Filaggrin gene defects substantially increase the risk of atopic eczema. The increased skin permeability may increase the risk of sensitization to food and other allergens, this pointing to the possible role of cutaneous allergen avoidance in early life to prevent the onset of atopic eczema and food allergy. Emerging evidence also indicates that oral exposure to potentially allergenic foods may be important for inducing immunological tolerance.
Allison Worth; Aziz Sheikh
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
Allergy & Respiratory Research Group, Centre for Population Health Sciences: General Practice Section, The University of Edinburgh, Edinburgh EH8 9AG, Scotland, UK.
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MeSH Terms
Allergens / administration & dosage,  adverse effects,  immunology
Dermatitis, Atopic* / complications,  epidemiology,  genetics
Desensitization, Immunologic*
Dietary Proteins / administration & dosage,  adverse effects,  immunology
Food Hypersensitivity* / complications,  epidemiology,  genetics
Genetic Predisposition to Disease
Immune Tolerance
Intermediate Filament Proteins / genetics*
Risk Factors
Reg. No./Substance:
0/Allergens; 0/Dietary Proteins; 0/Intermediate Filament Proteins; 0/filaggrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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