Document Detail


Food addiction and obesity: evidence from bench to bedside.
MedLine Citation:
PMID:  20648909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity has become a major health problem and epidemic. However, much of the current debate has been fractious and etiologies of obesity have been attributed to eating behavior or fast food, personality issues, depression, addiction, or genetics. One of the interesting new hypotheses for epidemic obesity is food addiction, which is associated with both substance-related disorder and eating disorder. Accumulating evidences have shown that there are many shared neural and hormonal pathways as well as distinct differences that may help researchers find why certain individuals overeat and become obese. Functional neuroimaging studies have further revealed that good or great smelling, looking, tasting, and reinforcing food has characteristics similar to that of drugs of abuse. Many of the brain changes reported for hedonic eating and obesity are also seen in various forms of addictions. Most importantly, overeating and obesity may have an acquired drive like drug addiction with respect to motivation and incentive; craving, wanting, and liking occur after early and repeated exposures to stimuli. The acquired drive for great food and relative weakness of the satiety signal would cause an imbalance between the drive and hunger/reward centers in the brain and their regulation.
Authors:
Yijun Liu; Karen M von Deneen; Firas H Kobeissy; Mark S Gold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of psychoactive drugs     Volume:  42     ISSN:  0279-1072     ISO Abbreviation:  J Psychoactive Drugs     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-22     Completed Date:  2010-08-26     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8113536     Medline TA:  J Psychoactive Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetitive Behavior
Brain / pathology,  physiopathology
Eating / physiology
Eating Disorders / genetics,  physiopathology
Food / adverse effects*
Humans
Obesity* / epidemiology,  etiology,  psychology
Prader-Willi Syndrome / physiopathology
Reward
Substance-Related Disorders* / complications,  etiology,  psychology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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