Document Detail


Food-related odor probes of brain reward circuits during hunger: a pilot FMRI study.
MedLine Citation:
PMID:  20339365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food aromas can be powerful appetitive cues in the natural environment. Although several studies have examined the cerebral responses to food images, none have used naturalistic food aromas to study obesity. Ten individuals (five normal-weight and five obese) were recruited to undergo 24 h of food deprivation. Subjects were then imaged on a 3T Siemens Trio-Tim scanner (Siemens, Erlangen, Germany) while smelling four food-related odors (FRO; two sweet odors and two fat-related) and four "nonappetitive odors" (NApO; e.g., Douglas fir). Before the imaging session, subjects rated their desire to eat each type of food to determine their most preferred (P-FRO). Across all 10 subjects, P-FRO elicited a greater blood oxygenation level dependent (BOLD) response than the NApO in limbic and reward-related areas, including the bilateral insula and opercular (gustatory) cortex, the anterior and posterior cingulate, and ventral striatum. Obese subjects showed greater activation in the bilateral hippocampus/parahippocampal gyrus, but lean controls showed more activation in the posterior insula. Brain areas activated by food odors are similar to those elicited by cues of addictive substances, such as alcohol. Food odors are highly naturalistic stimuli, and may be effective probes of reward-related networks in the context of hunger and obesity.
Authors:
Veronique Bragulat; Mario Dzemidzic; Carolina Bruno; Cari A Cox; Thomas Talavage; Robert V Considine; David A Kareken
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-25
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  18     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2011-02-10     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1566-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiology*
Brain Mapping
Cues
Female
Food*
Food Deprivation / physiology*
Food Preferences
Humans
Hunger / physiology*
Magnetic Resonance Imaging
Odors*
Pilot Projects
Reward*
Smell*
Stimulation, Chemical
Young Adult
Grant Support
ID/Acronym/Agency:
M01RR000750/RR/NCRR NIH HHS; R01 AA014605/AA/NIAAA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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