Document Detail

Fontan and the pulmonary circulation: a potential role for new pulmonary hypertension therapies.
MedLine Citation:
PMID:  20538665     Owner:  NLM     Status:  MEDLINE    
In recent decades, the Fontan procedure and its variations have resulted in markedly improved outcomes of patients with single-ventricle physiology. These improvements are expected to increase greatly the number of surviving patients, particularly those surviving long into adulthood. However, there is still a progressive risk of attrition and failure of the Fontan circulation over time, the underlying pathophysiology of which is not fully understood. Current evidence suggests that alterations in the structure and function of the pulmonary vasculature may play a pivotal role. Recent evidence suggests that therapies approved for pulmonary arterial hypertension may provide benefits in this increasingly important patient population.
Maurice Beghetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  911-6     Citation Subset:  AIM; IM    
Unité de Cardiologie Pédiatrique, Département de L'Enfant et de L'Adolescent, Hôpital des Enfants, 6 rue Willy Donzé, Geneva, Switzerland.
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MeSH Terms
Fontan Procedure / adverse effects*
Heart Defects, Congenital / surgery
Hypertension, Pulmonary / etiology*,  physiopathology,  therapy*
Protein-Losing Enteropathies / etiology,  therapy
Pulmonary Circulation / physiology*

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