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Fontan Hepatic Fibrosis and Pulmonary Vascular Development.
MedLine Citation:
PMID:  25381625     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fontan patients are at risk for hepatic fibrosis; however, risk factors are unclear. We performed a multivariate analysis in a small cohort of 14 patients (7-24 years old, mean 15) with Fontan circulation, undergoing cardiac catheterization and transvenous liver biopsies, all demonstrating fibrosis. We found by stepwise regression analysis that the history of pulmonary atresia was a predictor of higher total hepatic fibrosis scores than a history of unobstructed pulmonary blood flow (p = 0.002). Other variables including age, time from Fontan, hemodynamic measurements, and laboratory values were not predictive of total fibrosis scores at p values <0.05. Hepatic fibrosis scores between those born with pulmonary atresia versus unrestricted pulmonary blood flow may reflect differences in pulmonary circulatory physiology, resulting from differences in pulmonary vascular development.
Authors:
William N Evans; Ruben J Acherman; Brody J Winn; Noel S Yumiaco; Alvaro Galindo; Abraham Rothman; Humberto Restrepo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-9
Journal Detail:
Title:  Pediatric cardiology     Volume:  -     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-9     Completed Date:  -     Revised Date:  2014-11-10    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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