Document Detail


Fondaparinux as anticoagulant in a pregnant woman with heparin allergy.
MedLine Citation:
PMID:  16479197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a patient who had a history of deep vein thrombosis in a previous pregnancy. She was treated with heparins without any reactions in the index pregnancy. Subsequently, when the patient became pregnant again, she developed an acute cutaneous reaction to the low molecular heparin enoxaparin 3 weeks after initiation of therapy. She developed a similar reaction to delteparin as well. She was therefore treated with warfarin until 36 weeks of gestation. Then she was treated with fondaparinux (Arixtra, Sanofi-Synthelabo, Paris, France) 2.5 mg daily for the remainder of the pregnancy. Delivery was at term by induction of labour. Fondaparinux was stopped on the day of the induction of labour. It was re-started 6 h post-delivery and the patient was anticoagulated with warfarin in the post-partum period. There were no bleeding tendencies or recurrences of thrombosis during fondaparinux therapy. Both mother and baby were well after delivery.
Authors:
Ajith Wijesiriwardana; David A R Lees; Christopher Lush
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  17     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Cumberland Infirmary, Carlisle, UK. namal17@hotmail.co.uk
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / administration & dosage*
Drug Hypersensitivity* / etiology
Female
Fibrinolytic Agents / adverse effects
Heparin / adverse effects
Humans
Live Birth
Polysaccharides / administration & dosage*
Postpartum Period / drug effects
Pregnancy
Pregnancy Complications, Hematologic / prevention & control*
Venous Thrombosis / prevention & control*
Warfarin / administration & dosage
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Fibrinolytic Agents; 0/Polysaccharides; 0/fondaparinux; 81-81-2/Warfarin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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