| Follow-up of very low birth weight infants after erythropoietin treatment to prevent anemia of prematurity. | |
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MedLine Citation:
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PMID: 7636658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Treatment with recombinant human erythropoietin (rHuEPO) stimulates erythropoiesis and reduces the need for transfusions in hospitalized preterm infants. The aim of our study was to follow very low birth weight infants after the initial 6 weeks of rHuEPO treatment. DESIGN AND METHODS: We randomly assigned 97 very low birth weight infants with a gestational age of 31 weeks or less and birth weight of 1500 gm or less to receive rHuEPO, 300 units/kg per week (erythropoietin (EPO) 300, n = 33), rHuEPO, 750 units/kg per week (EPO 750; n = 28), or no treatment (control, n = 36). The rHuEPO was administered from the first week of life for 6 weeks. After EPO therapy was discontinued, 75 neonates were followed weekly until discharge and at 3, 6, and 12 months of age. RESULTS: Mean numbers (+/- SD) of packed erythrocyte transfusions per patient from the time rHuEPO therapy was discontinued until discharge were 0.38 +/- 0.64 (EPO 300), 0.23 +/- 0.52 (EPO 750), 0.9 +/- 1.1 (control) (p < 0.05 in both EPO groups vs control). Mean reticulocyte counts at the sixth week were 6% +/- 2.2% (EPO 300), 6.9% +/- 2.2% (EPO 750), and 3.1% +/- 2.6% (control) in the three groups (p < 0.01 in both EPO groups vs control), and at the eighth week were 4.7% +/- 2.8% (EPO 300), 5.4% +/- 2.7% (EPO 750), and 2.6% +/- 2.2% (control) (p < 0.01 in both EPO groups vs control). Serum ferritin levels were significantly higher at the sixth week, and the percentage of hemoglobin F was significantly lower at 6, 8, and 10 weeks in the control group versus EPO groups. At 3, 6, and 12 months of age, there were no differences in reticulocytes, ferritin, HbF, and growth among groups. CONCLUSION: Preterm infants who received rHuEPO had a normal pattern of erythropoiesis after the drug was discontinued. These data provide strong evidence that the anemia of prematurity is the result of a transient developmental abnormality in EPO production. |
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Authors:
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V Soubasi; G Kremenopoulos; E Diamanti; C Tsantali; K Sarafidis; D Tsakiris |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of pediatrics Volume: 127 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-11 Completed Date: 1995-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 291-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Neonatology, University of Thessaloniki, Hippokratio Hospital, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Neonatal
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blood,
epidemiology,
prevention & control* Drug Administration Schedule Erythropoiesis / physiology Erythropoietin / administration & dosage, therapeutic use* Ferritins / blood Follow-Up Studies Hematocrit Humans Infant, Low Birth Weight* Infant, Newborn Infant, Premature, Diseases / blood, epidemiology, prevention & control* Recombinant Proteins / administration & dosage, therapeutic use Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11096-26-7/Erythropoietin; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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