| Follow-up study of susceptibility loci for Alzheimer's disease and onset age identified by genome-wide association. | |
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MedLine Citation:
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PMID: 20308783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Replication of genetic association findings in independent studies represents an important validation tool in the search for susceptibility genes for complex diseases such as Alzheimer's disease (AD). In a well-characterized memory-clinic based study comprising 1078 unrelated AD patients and 652 control individuals, we set out to replicate previously reported genome-wide association of four novel risk SNPs with AD and onset age, with first stage p-values ranging from 0.001 to 0.000004. We obtained evidence for association between rs179943, an intronic SNP in ATXN1 at 6p22.3, and affection status (OR = 0.63 (95% CI = 0.44-0.90; nominal p = 0.01)). Overall, our data provided independent support for association of at least one chromosomal locus with AD and warranted a more in-depth investigation of these regions for possible underlying functional variants. |
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Authors:
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Karolien Bettens; Nathalie Brouwers; Helen Van Miegroet; Ana Gil; Sebastiaan Engelborghs; Peter P De Deyn; Rik Vandenberghe; Christine Van Broeckhoven; Kristel Sleegers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: 19 ISSN: 1875-8908 ISO Abbreviation: J. Alzheimers Dis. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-07-22 Revised Date: 2010-10-22 |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1169-75 Citation Subset: IM |
Affiliation:
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Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Aged Alzheimer Disease / genetics* Chromosomes, Human, Pair 6 / genetics DNA Replication / genetics Dementia, Vascular / genetics Female Follow-Up Studies Genetic Loci / genetics* Genetic Predisposition to Disease Genome-Wide Association Study / methods* Genotype Humans Introns Male Middle Aged Neurodegenerative Diseases / genetics Polymerase Chain Reaction Polymorphism, Single Nucleotide / genetics Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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