Document Detail

Follow-up study of a randomized controlled trial of postnatal dexamethasone therapy in very low birth weight infants: effects on pulmonary outcomes at age 8 to 11 years.
MedLine Citation:
PMID:  17382108     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether postnatal dexamethasone (DEX) exposure affects pulmonary outcomes at school age in children born with very low birth weight (VLBW).
STUDY DESIGN: Follow-up study of 68 VLBW children who participated in a randomized controlled trial of postnatal DEX. Pulmonary function was assessed by spirometry. Current asthma status was obtained from a parent.
RESULTS: Sixty-eight percent of the placebo group had below-normal forced expiratory volume in 1 second (FEV1), compared with 40% of the DEX group (chi2 = 4.84; P = .03), with trends for lower forced vital capacity (FVC) and FEV1 values in the placebo group. Fifty percent of the placebo group and 34% of DEX group had below normal FEV1/FVC (chi2 =1.59; P =.21). Parent-reported prevalence of asthma did not differ between groups. Logistic regression analysis suggested that the positive effects of DEX on pulmonary function at follow-up were mediated in part by shortened exposure to mechanical ventilation.
CONCLUSIONS: Postnatal DEX exposure was associated with higher expiratory flow with no adverse effects on pulmonary outcomes at school age. The prevalences of asthma and impaired pulmonary function underscore the influence of neonatal illness on health at school age, and stress the importance of repeated follow-up examinations of these children.
Patricia A Nixon; Lisa K Washburn; Michael S Schechter; T Michael O'Shea
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  150     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-04-11     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-50     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / complications,  diagnosis
Bronchopulmonary Dysplasia / complications,  drug therapy*
Child Development
Dexamethasone / therapeutic use*
Double-Blind Method
Follow-Up Studies
Glucocorticoids / therapeutic use*
Infant, Newborn
Infant, Very Low Birth Weight*
Logistic Models
Lung / drug effects*
Odds Ratio
Respiratory Function Tests
Grant Support
M01 RR007122-15/RR/NCRR NIH HHS; M01-RR07122/RR/NCRR NIH HHS; P01 HD047584/HD/NICHD NIH HHS; P01 HD047584-02/HD/NICHD NIH HHS; P01HD047584/HD/NICHD NIH HHS; R01 HD017644/HD/NICHD NIH HHS; R01 HD017644-25/HD/NICHD NIH HHS
Reg. No./Substance:
0/Glucocorticoids; 7S5I7G3JQL/Dexamethasone
Comment In:
J Pediatr. 2007 Apr;150(4):327-8   [PMID:  17382102 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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