| Follow-up study of peritoneal fluid kinetics in infants and children on peritoneal dialysis. | |
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MedLine Citation:
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PMID: 10641778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study longitudinal changes in transcapillary ultrafiltration (TCUF) and marker clearance (MC), as a reflection of lymphatic absorption, in children on peritoneal dialysis (PD). To present data on fluid kinetics in infants younger than 2.5 years, using an intraperitoneal volume of 1200 mL/m2 body surface area (BSA). DESIGN: The study involved a 4-hour dwell of 1200 mL/m2 BSA of dialysis fluid containing 3.86% glucose with Dextran 70 as volume marker. Cumulative TCUF and cumulative MC were measured. SETTING: A tertiary-care university hospital. PATIENTS: A follow-up period of 33 months of serial (1 - 4) peritoneal equilibration tests (PETs) was studied in 20 children with a median age of 6.4 years (range 2.1 - 15.4 years). Fluid kinetics in 5 additional infants with a median age of 1.4 years (range 0.5 - 2.5 years) was measured. RESULTS: Cumulative TCUF was 1041 mL/1.73 m2 at 1 - 3 months after start of PD, 1026 mL/1.73 m2 at 7 - 9 months, 1021 mL/1.73 m2 at 11 - 13 months, and 756 mL/1.73 m2 at 26 - 33 months (NS). Cumulative MC was 235 mL/1.73 m2 at 1 - 3 months after start of PD, 311 mL/1.73 m2 at 7 - 9 months, 395 mL/1.73 m2 at 11 - 13 months, and 509 mL/1.73 m2 at 26 - 33 months (NS). In infants, cumulative TCUF was 755 +/- 237 mL/1.73 m2; cumulative MC was 400 +/- 214 mL/1.73 m2. CONCLUSIONS: Transcapillary ultrafiltration and marker clearance do not change in children > 2.5 years during the period studied. Fluid kinetics does not differ between infants < 2.5 years and older children when intraperitoneal volumes of 1200 mL/m2 BSA are used. |
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Authors:
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A W de Boer; T C van Schaijk; H L Willems; A F de Haan; L A Monnens; C H Schröder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Volume: 19 ISSN: 0896-8608 ISO Abbreviation: Perit Dial Int Publication Date: 1999 Nov-Dec |
Date Detail:
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Created Date: 2000-02-01 Completed Date: 2000-02-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8904033 Medline TA: Perit Dial Int Country: CANADA |
Other Details:
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Languages: eng Pagination: 572-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University Hospital Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adolescent Age Factors Blood Glucose / analysis Body Surface Area Child Child, Preschool Creatinine / analysis, blood Dextrans / administration & dosage, analysis, pharmacokinetics Dialysis Solutions / administration & dosage, analysis, pharmacokinetics* Female Follow-Up Studies Glucose / administration & dosage, analysis, pharmacokinetics* Humans Longitudinal Studies Lymph / metabolism Male Peritoneal Dialysis* Peritoneum / metabolism Retrospective Studies Ultrafiltration |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dialysis Solutions; 50-99-7/Glucose; 60-27-5/Creatinine; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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