| Follow-up of soluble interleukin-2 receptor levels after thymectomy in patients with myasthenia gravis. | |
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MedLine Citation:
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PMID: 1730157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soluble interleukin-2 receptor (sIL-2R) levels were followed up after thymectomy by a quantitative immunoradiometric assay in 59 patients with myasthenia gravis (MG). Increased levels of sIL-2R were found in 30.5% of the patients before thymectomy. Serum levels were significantly higher in severely affected patients. Sequential sampling after thymectomy indicated a significant and progressive decline of sIL-2R levels within 2 years after surgery, which was well associated with clinical improvement or remission. The sIL-2R purified from sera of patients with MG had a molecular mass of 45 kDa as the normal sIL-2R. The decline after thymectomy of sIL-2R titers suggests a possible role of the thymus in the occurrence of sIL-2R in the periphery. Soluble IL-2R levels may represent a marker of disease severity in MG, which might be useful in the follow-up of individual patients. |
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Authors:
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S Cohen-Kaminsky; Y Jacques; C Aime; D Safar; E Morel; S Berrih-Aknin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical immunology and immunopathology Volume: 62 ISSN: 0090-1229 ISO Abbreviation: Clin. Immunol. Immunopathol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-02-20 Completed Date: 1992-02-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0356637 Medline TA: Clin Immunol Immunopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 190-8 Citation Subset: IM |
Affiliation:
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CNRS URA-1159, Laboratoire d'Immunologie, Hôpital Marie Lannelongue, Le Plessis-Robinson, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Chromatography, Affinity Electrophoresis, Polyacrylamide Gel Female Follow-Up Studies Humans Male Middle Aged Myasthenia Gravis / blood* Receptors, Interleukin-2 / metabolism* Solubility Thymectomy* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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