Document Detail


Follow-up of soluble interleukin-2 receptor levels after thymectomy in patients with myasthenia gravis.
MedLine Citation:
PMID:  1730157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Soluble interleukin-2 receptor (sIL-2R) levels were followed up after thymectomy by a quantitative immunoradiometric assay in 59 patients with myasthenia gravis (MG). Increased levels of sIL-2R were found in 30.5% of the patients before thymectomy. Serum levels were significantly higher in severely affected patients. Sequential sampling after thymectomy indicated a significant and progressive decline of sIL-2R levels within 2 years after surgery, which was well associated with clinical improvement or remission. The sIL-2R purified from sera of patients with MG had a molecular mass of 45 kDa as the normal sIL-2R. The decline after thymectomy of sIL-2R titers suggests a possible role of the thymus in the occurrence of sIL-2R in the periphery. Soluble IL-2R levels may represent a marker of disease severity in MG, which might be useful in the follow-up of individual patients.
Authors:
S Cohen-Kaminsky; Y Jacques; C Aime; D Safar; E Morel; S Berrih-Aknin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical immunology and immunopathology     Volume:  62     ISSN:  0090-1229     ISO Abbreviation:  Clin. Immunol. Immunopathol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-02-20     Completed Date:  1992-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356637     Medline TA:  Clin Immunol Immunopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  190-8     Citation Subset:  IM    
Affiliation:
CNRS URA-1159, Laboratoire d'Immunologie, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myasthenia Gravis / blood*
Receptors, Interleukin-2 / metabolism*
Solubility
Thymectomy*
Chemical
Reg. No./Substance:
0/Receptors, Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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