Document Detail

Follow-up of preterm infants treated with dexamethasone for chronic lung disease.
MedLine Citation:
PMID:  8506835     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the outcome of prolonged treatment with dexamethasone sodium phosphate in preterm infants who depend on assisted ventilation. DESIGN: Longitudinal follow-up using historic controls. SETTING: Regional intensive care nursery. PARTICIPANTS: Sixty-one very-low-birth-weight infants treated with a 42-day course of dexamethasone and 61 historic controls matched for birth weight, gestational age, race, and sex. All 122 subjects required assisted ventilation for at least 15 days. INTERVENTION: Infants were given dexamethasone sodium phosphate at a dose of 0.5 mg/kg per day. The dose was then tapered over 42 days. MEASUREMENTS/MAIN RESULTS: Infants treated with dexamethasone received assisted ventilation for a median of 33 days; controls, a median of 47 days (P < .05). One hundred infants survived; 94 were examined at age 1 year. The two groups were similar with respect to the proportions hospitalized for respiratory infection in the first year of life and the proportions with weight, length, and head circumference below the fifth percentile. Rates of cerebral palsy were also similar between the two groups, as were median Bayley Mental and Psychomotor developmental index scores. CONCLUSIONS: Dexamethasone treatment was associated with fewer days of assisted ventilation, but not with improved outcome at age 1 year. More assessment should be made of dexamethasone's effect on long-term outcome before dexamethasone becomes widely used in preterm infants who depend on assisted ventilation.
T M O'Shea; J M Kothadia; K L Klinepeter; D J Goldstein; B Jackson; R G Dillard
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  147     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-07     Completed Date:  1993-07-07     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  658-61     Citation Subset:  AIM; IM    
Department of Pediatrics, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.
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MeSH Terms
Chronic Disease
Combined Modality Therapy
Dexamethasone / analogs & derivatives*,  therapeutic use
Follow-Up Studies
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature, Diseases / therapy*
Longitudinal Studies
Lung Diseases / therapy*
Respiration, Artificial*
Time Factors
Treatment Outcome
Reg. No./Substance:
312-93-6/dexamethasone 21-phosphate; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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