| Follow-up of latency and threshold shifts of auditory brainstem responses after single and interrupted acoustic trauma in guinea pig. | |
| | |
MedLine Citation:
|
PMID: 19766602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thresholds of auditory brainstem responses (ABRs) are widely used to estimate the level of noise-induced hearing loss or the level of acquired resistance to acoustic trauma after repeated exposures, i.e., the "toughening" effect. Less is known about ABR latencies and their relation to threshold changes. Guinea pigs were exposed to a traumatic pure tone at 5 kHz, 120 dB SPL, as either single (2 h, 4 h) or repeated (1 h every 48 h, four times) sessions. Thresholds and latencies of ABRs were monitored up to 45 days following the acoustic trauma. We show that latencies are prolonged in the case of large temporary threshold shifts observed in the days following trauma. The latency shift decreases after several repeated exposures, then stabilizes, similar to thresholds, suggesting that the "toughening" effect also applies to latencies. Permanent latency shift is usually very small compared to the permanent threshold shift. This effect could produce a recovery in the ability to process auditory information through the precise timing of neuronal events. Our study indicates that when estimated at suprathreshold stimulation level (70 dB SPL), latency provides complementary information to the sole threshold. |
| | |
Authors:
|
Boris Gour??vitch; Thibaut Doisy; Marie Avillac; Jean-Marc Edeline |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-18 |
Journal Detail:
|
Title: Brain research Volume: 1304 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-17 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 66-79 Citation Subset: IM |
Affiliation:
|
Laboratoire de Neurobiologie de l'Apprentissage, de la M??moire et de la Communication, UMR CNRS 8620, Universit?? Paris-Sud, 91405 Orsay cedex, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation Animals Audiometry, Evoked Response Auditory Pathways / physiopathology Auditory Threshold Brain Stem / physiopathology* Evoked Potentials, Auditory, Brain Stem* Female Follow-Up Studies Guinea Pigs Hearing Loss, Noise-Induced / physiopathology* Male Pressure Reproducibility of Results Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: Potential for understanding NKX2.1 ha...
Next Document: Long-term functional and neurological outcome after simultaneous treatment with tissue-plasminogen a...