Document Detail

Follow-up of latency and threshold shifts of auditory brainstem responses after single and interrupted acoustic trauma in guinea pig.
MedLine Citation:
PMID:  19766602     Owner:  NLM     Status:  MEDLINE    
Thresholds of auditory brainstem responses (ABRs) are widely used to estimate the level of noise-induced hearing loss or the level of acquired resistance to acoustic trauma after repeated exposures, i.e., the "toughening" effect. Less is known about ABR latencies and their relation to threshold changes. Guinea pigs were exposed to a traumatic pure tone at 5 kHz, 120 dB SPL, as either single (2 h, 4 h) or repeated (1 h every 48 h, four times) sessions. Thresholds and latencies of ABRs were monitored up to 45 days following the acoustic trauma. We show that latencies are prolonged in the case of large temporary threshold shifts observed in the days following trauma. The latency shift decreases after several repeated exposures, then stabilizes, similar to thresholds, suggesting that the "toughening" effect also applies to latencies. Permanent latency shift is usually very small compared to the permanent threshold shift. This effect could produce a recovery in the ability to process auditory information through the precise timing of neuronal events. Our study indicates that when estimated at suprathreshold stimulation level (70 dB SPL), latency provides complementary information to the sole threshold.
Boris Gour??vitch; Thibaut Doisy; Marie Avillac; Jean-Marc Edeline
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-18
Journal Detail:
Title:  Brain research     Volume:  1304     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  66-79     Citation Subset:  IM    
Laboratoire de Neurobiologie de l'Apprentissage, de la M??moire et de la Communication, UMR CNRS 8620, Universit?? Paris-Sud, 91405 Orsay cedex, France.
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MeSH Terms
Acoustic Stimulation
Audiometry, Evoked Response
Auditory Pathways / physiopathology
Auditory Threshold
Brain Stem / physiopathology*
Evoked Potentials, Auditory, Brain Stem*
Follow-Up Studies
Guinea Pigs
Hearing Loss, Noise-Induced / physiopathology*
Reproducibility of Results
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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