| Follow-up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation. | |
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MedLine Citation:
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PMID: 15496869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effect of hydroxychloroquine treatment during pregnancy and lactation on babies of mothers affected by rheumatic diseases. STUDY DESIGN AND METHODS: A total of 40 infants born from mothers affected by rheumatic diseases and treated with hydroxychloroquine during pregnancy were enrolled in a prospective observational study. Main outcome measures at birth were incidence of prematurity, congenital malformations and neonatal infections. Of these babies, including 13 who were breast-fed, 24 were followed up during early infancy for visual function and neurodevelopmental outcome. RESULTS: Preterm delivery was the main complication (20.5%). No significant congenital malformations or neonatal infections were detected. All infants, including those who were breast-fed, had normal visual function and neurodevelopmental outcome. CONCLUSIONS: Hydroxychloroquine treatment during gestation and lactation appeared to be safe. The relatively high incidence of preterm deliveries may reflect the maternal disease state. |
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Authors:
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Mario Motta; Angela Tincani; David Faden; Enrica Zinzini; Andrea Lojacono; Alessandra Marchesi; Micol Frassi; Chiara Biasini; Sonia Zatti; Gaetano Chirico |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 25 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-20 Completed Date: 2005-06-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 86-9 Citation Subset: IM |
Affiliation:
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Division of Neonatology and NICU (M.M., A.M., G.C.), Spedali Civili - Brescia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antirheumatic Agents
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adverse effects*,
therapeutic use Breast Feeding* Child Development / drug effects* Female Follow-Up Studies Humans Hydroxychloroquine / adverse effects*, therapeutic use Infant, Newborn Male Pregnancy Pregnancy Complications / drug therapy* Premature Birth / etiology Rheumatic Diseases / complications, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 118-42-3/Hydroxychloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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