Document Detail

Follow-up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation.
MedLine Citation:
PMID:  15496869     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect of hydroxychloroquine treatment during pregnancy and lactation on babies of mothers affected by rheumatic diseases. STUDY DESIGN AND METHODS: A total of 40 infants born from mothers affected by rheumatic diseases and treated with hydroxychloroquine during pregnancy were enrolled in a prospective observational study. Main outcome measures at birth were incidence of prematurity, congenital malformations and neonatal infections. Of these babies, including 13 who were breast-fed, 24 were followed up during early infancy for visual function and neurodevelopmental outcome. RESULTS: Preterm delivery was the main complication (20.5%). No significant congenital malformations or neonatal infections were detected. All infants, including those who were breast-fed, had normal visual function and neurodevelopmental outcome. CONCLUSIONS: Hydroxychloroquine treatment during gestation and lactation appeared to be safe. The relatively high incidence of preterm deliveries may reflect the maternal disease state.
Mario Motta; Angela Tincani; David Faden; Enrica Zinzini; Andrea Lojacono; Alessandra Marchesi; Micol Frassi; Chiara Biasini; Sonia Zatti; Gaetano Chirico
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  25     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-20     Completed Date:  2005-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-9     Citation Subset:  IM    
Division of Neonatology and NICU (M.M., A.M., G.C.), Spedali Civili - Brescia, Italy.
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MeSH Terms
Antirheumatic Agents / adverse effects*,  therapeutic use
Breast Feeding*
Child Development / drug effects*
Follow-Up Studies
Hydroxychloroquine / adverse effects*,  therapeutic use
Infant, Newborn
Pregnancy Complications / drug therapy*
Premature Birth / etiology
Rheumatic Diseases / complications,  drug therapy*
Reg. No./Substance:
0/Antirheumatic Agents; 118-42-3/Hydroxychloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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