Document Detail


Follow-up clinic and ambulatory blood pressure in untreated white-coat hypertensive patients (evaluation after 2-5 years).
MedLine Citation:
PMID:  10388905     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: It is still under debate whether subjects with persistently elevated clinic blood pressure but normal ambulatory blood pressure, [white-coat hypertensives (WCH)] have a higher propensity for further development of ambulatory hypertension. METHODS: We prospectively evaluated for 3.5 years (from 26 up to 59 months) the transition of clinic and ambulatory blood pressure values in 36 untreated subjects (17-65 years) with WCH (clinic blood pressure > 140/90 and awake ambulatory blood pressure < 132/84 mmHg and without any other major cardiovascular risk factors) and of 52 clinic and ambulatory normotensive subjects (clinic blood pressure < 140/90 mmHg and awake blood pressure < 132/84 mmHg, 24-61 years). RESULTS: Average values of clinic blood pressure, 24 h blood pressure and awake blood pressure values did not differ from baseline to the end of the follow-up period in both populations. Development of ambulatory hypertension occurred in four out of 36 (11%) subjects with WCH and in three out of 52 (6%) normotensives if defined by awake blood pressure >/= 140/90 mmHg and in eight out of 36 (22%) subjects with WCH and in eight out of 52 (15%) normotensives if defined by awake blood pressure >/= 132/84 mmHg, respectively. Patients who reached ambulatory hypertension had baseline awake blood pressure values within the upper quintile of distribution of blood pressure in their respective group. CONCLUSION: After an average of 3.5 years of follow-up, a transition to ambulatory hypertension occurred in a similar way in normotensives and subjects with WCH without any other cardiovascular risk. A small propensity for the development of sustained hypertension may affect patients with higher initial ambulatory blood pressure values. Although a slow evolution towards sustained hypertension cannot be excluded in subjects with WCH, these findings suggest that this transition might be similar to that in normotensive subjects.
Authors:
Polónia; Santos; Gama; Basto; Bettencourt; Martins
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  2     ISSN:  1473-5725     ISO Abbreviation:  Blood Press Monit     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1999-07-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  -    
Other Details:
Languages:  ENG     Pagination:  289-295     Citation Subset:  -    
Affiliation:
Unidade de Farmacologia Clinica, Portol Portugal.
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