Document Detail


Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year.
MedLine Citation:
PMID:  8565248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult patients with severe atopic eczema who had completed a double-blind placebo-controlled crossover trial of a specific formulation of Chinese herbal therapy were offered continued therapy for 1 year. Of 31 patients who completed the original placebo-controlled study and after a washout period and 2 months of further treatment, 17 continued treatment (group 1), 11 chose not to continue treatment (group 2), one was lost to follow-up and two patients originally in group 1 decided to stop treatment and became pregnant. At the end of the year, 12 of the patients in group 1 had greater than 90% reduction and the remaining five had greater than 60% reduction in clinical scores compared with baseline values. Clinical scores of patients in group 2 gradually deteriorated so that by the end of the year the difference between groups 1 and 2 was highly significant (P = 0.005 and P = 0.002 for erythema and surface damage, respectively). At the end of the year no patient in group 1 felt able to discontinue treatment permanently, but eight patients were on an alternate-day regimen by 6 months and remained on this regimen until the end of the year, and seven were able to control their eczema with a 1 in every 3 day treatment by the end of the year. The remaining two patients continued on daily treatments. Toxicology screening revealed no abnormalities in either full blood counts or biochemical parameters in any patient on continued treatment. Improvement in disease was not associated with any significant change in serum IgE level or peripheral blood lymphocyte subsets.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M P Sheehan; H Stevens; L S Ostlere; D J Atherton; J Brostoff; M H Rustin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  20     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1996-03-06     Completed Date:  1996-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Royal Free Hospital, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Over Studies
Dermatitis, Atopic / drug therapy*,  physiopathology
Double-Blind Method
Drugs, Chinese Herbal / administration & dosage,  adverse effects,  therapeutic use*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Patient Compliance
Regression Analysis
Treatment Outcome
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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