Document Detail


Follistatin-Like 3 Across Gestation in Preeclampsia and Uncomplicated Pregnancies Among Lean and Obese Women.
MedLine Citation:
PMID:  24700053     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this study was to examine circulating maternal follistatin-like 3 (FSTL-3) by gestational age and obesity in pregnancy and preeclampsia. FSTL-3 was quantified in maternal plasma collected in each trimester from prepregnancy body mass index-determined groups: 15 lean and 24 obese controls and 20 obese women who developed preeclampsia. Repeated measures mixed models and logistic regression were conducted (P ≤ .05). FSTL-3 was not related to maternal adiposity. FSTL-3 changed across pregnancy in lean controls and obese preeclampsia but not in obese controls. FSTL-3 was higher in preeclampsia in the second trimester compared to lean controls and in the third trimester compared to both control groups. Elevated FSTL-3 at mid-gestation was associated with an increased odds of preeclampsia (odds ratio 3.15; 95% confidence interval 1.19-8.36; P = .02). Elevated FSTL-3 concentrations were attributable to preeclampsia and were associated with increased likelihood of later developing preeclampsia, suggesting further study as a biomarker prior to clinically evident disease.
Authors:
Sandra A Founds; Dianxu Ren; James M Roberts; Arun Jeyabalan; Robert W Powers
Related Documents :
21252863 - Histidine-rich glycoprotein as an early biomarker of preeclampsia.
11499323 - Influence of midluteal serum prolactin on outcome of pregnancy after ivf-et: a prelimin...
2067763 - High-resolution endovaginal ultrasonography of the endometrium: a noninvasive test for ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-3
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  -     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recurrent Miscarriage and Micro-RNA Among North Indian Women.
Next Document:  Matrix Metalloproteinases 2 and 9 and E-Cadherin Expression in the Endometrium During the Implantati...