Document Detail


Follicular shuttling of marginal zone B cells facilitates antigen transport.
MedLine Citation:
PMID:  18037889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The splenic marginal zone is a site of blood flow, and the specialized B cell population that inhabits this compartment has been linked to the capture and follicular delivery of blood-borne antigens. However, the mechanism of this antigen transport has remained unknown. Here we show that marginal zone B cells were not confined to the marginal zone but continuously shuttled between the marginal zone and follicular areas, such that many of the cells visited a follicle every few hours. Migration to the follicle required the chemokine receptor CXCR5, whereas return to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P1 and S1P3. Treatment with an S1P1 antagonist caused displacement of marginal zone B cells from the marginal zone. Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells.
Authors:
Guy Cinamon; Marcus A Zachariah; Olivia M Lam; Frank W Foss; Jason G Cyster
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-11-25
Journal Detail:
Title:  Nature immunology     Volume:  9     ISSN:  1529-2916     ISO Abbreviation:  Nat. Immunol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-04-16     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  100941354     Medline TA:  Nat Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-62     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens / blood,  metabolism*
B-Lymphocytes / physiology*
Biological Transport
Dendritic Cells, Follicular / immunology
Mice
Mice, Knockout
Propylene Glycols / pharmacology
Receptors, CXCR5 / genetics,  physiology
Receptors, Lysosphingolipid / antagonists & inhibitors,  physiology
Sphingosine / analogs & derivatives,  pharmacology
Spleen / cytology,  immunology
Grant Support
ID/Acronym/Agency:
AI40098/AI/NIAID NIH HHS; R37 AI040098-08/AI/NIAID NIH HHS; R37 AI040098-09/AI/NIAID NIH HHS; R37 AI040098-10/AI/NIAID NIH HHS; R37 AI040098-11/AI/NIAID NIH HHS; R37 AI040098-12/AI/NIAID NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Antigens; 0/Edg3 protein, mouse; 0/Propylene Glycols; 0/Receptors, CXCR5; 0/Receptors, Lysosphingolipid; 123-78-4/Sphingosine; 3QN8BYN5QF/fingolimod
Comments/Corrections
Comment In:
Nat Immunol. 2008 Jan;9(1):11-2   [PMID:  18087249 ]

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