| Follicular mycosis fungoides: a histopathologic, immunohistochemical, and genotypic review. | |
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MedLine Citation:
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PMID: 19169213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Follicular mycosis fungoides (FMF) is a recognized variant of mycosis fungoides. In this review, the authors characterize the distinct histopathological and immunohistochemical patterns of FMF that have been reported in the literature. This article is an extensive review of the literature cited in Medline and own data of the authors. The major patterns of FMF histopathology, immunohistochemistry, and molecular genetics are summarized in this review. Histologically, the quintessential finding in FMF is small to medium atypical CD3+ CD4+ CD8- T lymphocytes around and within the epithelium of the hair follicles. This finding is requisite to the diagnosis. However, this finding may be obscured by a host of other patterns often identified in FMF. This includes basaloid folliculo-lymphoid hyperplasia, a granulomatous reaction, eosinophilic folliculitis, and follicular cystic changes with subtle atypical lymphocytes in the cyst wall. Follicular mucinosis (MF) and syringo-tropism are also variably present. Immunohistochemistry of all reported cases uniformly show a CD4+ T cell infiltrate. This review emphasizes and discusses the broad spectrum of histologic changes which may be seen in FMF, clues to the diagnosis, and some potential mimickers. |
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Authors:
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S L Boone; J Guitart; P Gerami |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia Volume: 143 ISSN: 0392-0488 ISO Abbreviation: G Ital Dermatol Venereol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-04-03 Revised Date: 2012-07-30 |
Medline Journal Info:
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Nlm Unique ID: 8102852 Medline TA: G Ital Dermatol Venereol Country: Italy |
Other Details:
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Languages: eng Pagination: 409-14 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD3
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analysis Antigens, CD4 / analysis Antigens, CD45 / analysis CD8-Positive T-Lymphocytes / immunology Genotype Hair Follicle / immunology* Humans Immunohistochemistry Mucinosis, Follicular / genetics*, immunology, pathology* Mycosis Fungoides / diagnosis, genetics*, immunology, pathology* Phenotype Skin Neoplasms / diagnosis, genetics*, immunology, pathology* T-Lymphocytes / immunology* Tumor Markers, Biological / analysis*, genetics, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD3; 0/Antigens, CD4; 0/Tumor Markers, Biological; EC 3.1.3.48/Antigens, CD45 |
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