Document Detail


Follicular mycosis fungoides: a histopathologic, immunohistochemical, and genotypic review.
MedLine Citation:
PMID:  19169213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Follicular mycosis fungoides (FMF) is a recognized variant of mycosis fungoides. In this review, the authors characterize the distinct histopathological and immunohistochemical patterns of FMF that have been reported in the literature. This article is an extensive review of the literature cited in Medline and own data of the authors. The major patterns of FMF histopathology, immunohistochemistry, and molecular genetics are summarized in this review. Histologically, the quintessential finding in FMF is small to medium atypical CD3+ CD4+ CD8- T lymphocytes around and within the epithelium of the hair follicles. This finding is requisite to the diagnosis. However, this finding may be obscured by a host of other patterns often identified in FMF. This includes basaloid folliculo-lymphoid hyperplasia, a granulomatous reaction, eosinophilic folliculitis, and follicular cystic changes with subtle atypical lymphocytes in the cyst wall. Follicular mucinosis (MF) and syringo-tropism are also variably present. Immunohistochemistry of all reported cases uniformly show a CD4+ T cell infiltrate. This review emphasizes and discusses the broad spectrum of histologic changes which may be seen in FMF, clues to the diagnosis, and some potential mimickers.
Authors:
S L Boone; J Guitart; P Gerami
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia     Volume:  143     ISSN:  0392-0488     ISO Abbreviation:  G Ital Dermatol Venereol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-04-03     Revised Date:  2012-07-30    
Medline Journal Info:
Nlm Unique ID:  8102852     Medline TA:  G Ital Dermatol Venereol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  409-14     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD3 / analysis
Antigens, CD4 / analysis
Antigens, CD45 / analysis
CD8-Positive T-Lymphocytes / immunology
Genotype
Hair Follicle / immunology*
Humans
Immunohistochemistry
Mucinosis, Follicular / genetics*,  immunology,  pathology*
Mycosis Fungoides / diagnosis,  genetics*,  immunology,  pathology*
Phenotype
Skin Neoplasms / diagnosis,  genetics*,  immunology,  pathology*
T-Lymphocytes / immunology*
Tumor Markers, Biological / analysis*,  genetics,  immunology
Chemical
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, CD4; 0/Tumor Markers, Biological; EC 3.1.3.48/Antigens, CD45

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