Document Detail

Follicular mucinosis: a critical reappraisal of clinicopathologic features and association with mycosis fungoides and Sézary syndrome.
MedLine Citation:
PMID:  11843637     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Beginning in 1957, patients have been described with localized alopecia characterized histopathologically by mucin deposition within hair follicles (follicular mucinosis [FM]). At least 2 distinct diagnostic entities have been proposed: one occurring in children and young adults without association with other diseases ("idiopathic" FM), the other occurring in elderly patients and associated with mycosis fungoides or Sézary syndrome ("lymphoma-associated" FM). OBJECTIVE: To determine whether idiopathic and lymphoma-associated FM are distinct or related entities. DESIGN: Case series. SETTING: Department of Dermatology, University of Graz, Graz, Austria. PATIENTS: Forty-four patients with FM were divided into 2 groups. Group 1 comprised 16 patients (mean age, 37.5 years) with no associated mycosis fungoides or Sézary syndrome; group 2 was made up of the other 28 (mean age, 52.2 years), who had clinicopathologic evidence of cutaneous T-cell lymphoma. RESULTS: Mean age was lower in patients with idiopathic FM, but a considerable overlapping among the 2 groups was present. Location on the head and neck region was common in both groups, but most patients with lymphoma-associated FM had lesions also on other body sites. In fact, solitary lesions at presentation were common in patients with idiopathic FM (11 [68.8%] of 16 patients), but uncommon in those with lymphoma-associated FM (2 [7.1%] of 28 patients). Histopathologic findings did not allow clear-cut differentiation of the 2 groups. Finally, a monoclonal rearrangement of the T-cell receptor gamma gene was demonstrated by polymerase chain reaction analysis in about 50% of tested cases from each group. CONCLUSIONS: Criteria previously reported to differentiate idiopathic from lymphoma-associated FM proved ineffective. In analogy to localized pagetoid reticulosis (Woringer-Kolopp disease), small-plaque parapsoriasis, and so-called solitary mycosis fungoides, idiopathic FM may represent a form of localized cutaneous T-cell lymphoma.
Lorenzo Cerroni; Regina Fink-Puches; Barbara Bäck; Helmut Kerl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  138     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-14     Completed Date:  2002-04-02     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182-9     Citation Subset:  AIM; IM    
Department of Dermatology, University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria.
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MeSH Terms
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Middle Aged
Mucinosis, Follicular / complications,  genetics,  pathology*
Mycosis Fungoides / complications*
Polymerase Chain Reaction
Sezary Syndrome / complications*
Skin Neoplasms / complications*
Comment In:
Arch Dermatol. 2002 Feb;138(2):244-6   [PMID:  11843646 ]
Arch Dermatol. 2002 Dec;138(12):1613-4; author reply 1614-5   [PMID:  12472358 ]
Arch Dermatol. 2002 Dec;138(12):1615   [PMID:  12472360 ]

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