| Follicular mucinosis: a critical reappraisal of clinicopathologic features and association with mycosis fungoides and Sézary syndrome. | |
| | |
MedLine Citation:
|
PMID: 11843637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Beginning in 1957, patients have been described with localized alopecia characterized histopathologically by mucin deposition within hair follicles (follicular mucinosis [FM]). At least 2 distinct diagnostic entities have been proposed: one occurring in children and young adults without association with other diseases ("idiopathic" FM), the other occurring in elderly patients and associated with mycosis fungoides or Sézary syndrome ("lymphoma-associated" FM). OBJECTIVE: To determine whether idiopathic and lymphoma-associated FM are distinct or related entities. DESIGN: Case series. SETTING: Department of Dermatology, University of Graz, Graz, Austria. PATIENTS: Forty-four patients with FM were divided into 2 groups. Group 1 comprised 16 patients (mean age, 37.5 years) with no associated mycosis fungoides or Sézary syndrome; group 2 was made up of the other 28 (mean age, 52.2 years), who had clinicopathologic evidence of cutaneous T-cell lymphoma. RESULTS: Mean age was lower in patients with idiopathic FM, but a considerable overlapping among the 2 groups was present. Location on the head and neck region was common in both groups, but most patients with lymphoma-associated FM had lesions also on other body sites. In fact, solitary lesions at presentation were common in patients with idiopathic FM (11 [68.8%] of 16 patients), but uncommon in those with lymphoma-associated FM (2 [7.1%] of 28 patients). Histopathologic findings did not allow clear-cut differentiation of the 2 groups. Finally, a monoclonal rearrangement of the T-cell receptor gamma gene was demonstrated by polymerase chain reaction analysis in about 50% of tested cases from each group. CONCLUSIONS: Criteria previously reported to differentiate idiopathic from lymphoma-associated FM proved ineffective. In analogy to localized pagetoid reticulosis (Woringer-Kolopp disease), small-plaque parapsoriasis, and so-called solitary mycosis fungoides, idiopathic FM may represent a form of localized cutaneous T-cell lymphoma. |
| | |
Authors:
|
Lorenzo Cerroni; Regina Fink-Puches; Barbara Bäck; Helmut Kerl |
Related Documents
:
|
10800987 - Increased incidence of follicular lymphoma in the duodenum. 22440997 - Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor ag... 12895397 - Dermatomyositis and polymyositis. 19417887 - Malignant transformation of oral lichen planus: a retrospective study of 23 cases. 8712747 - Itraconazole can increase systemic exposure to busulfan in patients given bone marrow t... 2775637 - Cervical wound hematoma after carotid endarterectomy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives of dermatology Volume: 138 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 2002 Feb |
Date Detail:
|
Created Date: 2002-02-14 Completed Date: 2002-04-02 Revised Date: 2008-03-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 182-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Dermatology, University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria. lorenzo.cerroni@kfunigraz.ac.at. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Female Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Humans Immunohistochemistry Male Middle Aged Mucinosis, Follicular / complications, genetics, pathology* Mycosis Fungoides / complications* Polymerase Chain Reaction Sezary Syndrome / complications* Skin Neoplasms / complications* |
| Comments/Corrections | |
Comment In:
|
Arch Dermatol. 2002 Feb;138(2):244-6
[PMID:
11843646
]
Arch Dermatol. 2002 Dec;138(12):1613-4; author reply 1614-5 [PMID: 12472358 ] Arch Dermatol. 2002 Dec;138(12):1615 [PMID: 12472360 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Water as a structural element in a channel: gating in the Kcsa channel, and implications for voltage...
Next Document: Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucino...