Document Detail

Follicular lymphoma with marked monocytoid or plasmacytoid differentiation and tiny or indistinct follicles: a case study of four patients.
MedLine Citation:
PMID:  21338287     Owner:  NLM     Status:  Publisher    
We report four cases of exceptional follicular lymphoma (FL) showing marked monocytoid or plasmacytoid differentiation and tiny or indistinct follicles, mimicking marginal zone lymphoma or plasma cell neoplasm. The lymphoma of patient 2 had lymphoepithelial lesions. The lymphoma of patient 4, who had a history of typical FL, was composed of only monocytoid cells, suggesting secondary involvement of the monocytoid component of FL. The lymphomas of patients 1 and 2 had tiny follicles immunoreactive with CD10 and BCL-2, whereas samples from patients 3 and 4 were negative for CD10. Fluorescence in situ hybridization (FISH) analysis showed IGH/BCL2 fusion in three of the four lymphomas (patients 1, 3, and 4). Histological analysis showed time- and site-dependent differences in FL characteristics in patients 2 and 4. Identifying tiny CD10+/BCL-2+ neoplastic follicles, detecting IGH/BCL2 fusion by FISH, and considering a history of FL are crucial for diagnosing such exceptional cases of FL.
Kenji Yamada; Akiko Miyagi Maeshima; Hirokazu Taniguchi; Yoshinori Kawabata; Junko Nomoto; Dai Maruyama; Sung-Won Kim; Takashi Watanabe; Yukio Kobayashi; Kensei Tobinai; Hitoshi Tsuda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-21
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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