| Follicular hyperplasia, follicular lysis, and progressive transformation of germinal centers. A sequential spectrum of morphologic evolution in lymphoid hyperplasia. | |
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MedLine Citation:
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PMID: 14502795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied mantle B-cell and T-cell ingression in hyperplastic follicles (HFs), follicular lysis (FL), and progressive transformation of germinal centers (PTGC) in 19 paraffin-embedded, H&E-, bcl-2-, CD20-, and CD3-stained lymph nodes. We enumerated the T cells (CD3+) and mantle B cells (bcl-2+/CD3-) per 100 cells in 5 high-power fields of each entity (mean +/- SD). Compared with HF, FL had increased numbers of T cells migrating into germinal centers (39.8 +/- 10.0 vs 25.8 +/- 7.8; P < .0001). and a mild increase of mantle B cells (12.3 +/- 11.4 vs 2.1 +/- 1.6; P < .001). PTGC showed an increase of T-cell ingression compared with HF (36.5 +/- 12.1 vs 25.8 +/- 7.8; P < .0001) and more migration of mantle B cells into the follicle than FL (41.0 +/- 22.5 vs 12.3 +/- 11.4; P < .0001). T cells and mantle B cells ingress in FL and PTGC, although the mantle B-cell component predominates in the latter, suggesting that follicular hyperplasia, FL, and PTGC constitute an evolutionary spectrum in resolution of lymphoid hyperplasia with sequential ingression of T cells followed by mantle B cells. The maintenance of bcl-2 expression in mantle B cells in PTGC may cause differential diagnostic pitfalls in florid PTGC vs follicular lymphoma, particularly the so-called floral variant. |
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Authors:
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Chung-Che Chang; Vladimir Osipov; Sue Wheaton; Sheryl Tripp; Sherrie L Perkins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of clinical pathology Volume: 120 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-23 Completed Date: 2003-10-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 322-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Medical College of Wisconsin, Milwaukee, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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B-Lymphocytes
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pathology Diagnosis, Differential Germinal Center* / pathology Humans Immunophenotyping Lymphoma, Follicular / pathology Pseudolymphoma / pathology* T-Lymphocytes / pathology |
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