| Follicular growth and oocyte maturation in GnRH agonist and antagonist protocols for in vitro fertilisation and embryo transfer. | |
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MedLine Citation:
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PMID: 19340626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to evaluate the response to treatment in a group of patients undergoing IVF and randomised to receive GnRH-antagonist or the GnRH-agonist. The endpoints were the pattern of follicular growth, the maturity of the oocytes collected, the embryo quality and the pregnancy outcome. METHODS: A total of 136 patients undergoing IVF were included. Sixty-seven patients were allocated to the GnRH antagonist and 69 patients to the GnRH agonist. GnRH antagonist was administered when the leading follicle reached a diameter of 12-14 mm. GnRH agonist was administered in a long luteal protocol. RESULTS: The mean numbers of oocytes retrieved and mature oocytes were significantly higher in the agonist than in the antagonist group (p < 0.02 and p < 0.01, respectively). Embryo quality, implantation rate, clinical pregnancy rates, ongoing pregnancy rate and miscarriage rate were similar in both groups. CONCLUSIONS: Better follicular growth and oocyte maturation are achieved with GnRH agonist treatment. However, both regimens seem to have similar efficacy in terms of implantation and pregnancy rates. Further studies clarifying the effect of the GnRH antagonist on ovarian function are needed, as well as a clear definition of the best period of the follicular phase for the GnRH antagonist administration. |
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Authors:
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Raffaella Depalo; Filomenamila Lorusso; Marcella Palmisano; Emma Bassi; Ilaria Totaro; Margherita Vacca; Paolo Trerotoli; Paola Masciandaro; Luigi Selvaggi |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 25 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 328-34 Citation Subset: IM |
Affiliation:
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Department of Gynecology, Obstetrics and Neonatology, Gynecology and Obstetric Unit A, University of Bari, Piazza Giulio Cesare, Bari, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Embryo Transfer Embryo, Mammalian / drug effects Female Fertilization in Vitro Gonadotropin-Releasing Hormone / agonists*, antagonists & inhibitors* Humans Oocytes / drug effects*, growth & development Ovarian Follicle / drug effects* Ovulation Induction / methods* Pregnancy Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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