Document Detail


Follicular dendritic cells produce IL-15 that enhances germinal center B cell proliferation in membrane-bound form.
MedLine Citation:
PMID:  15557159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Factors that control the survival and proliferation of Ag-stimulated B cells within the germinal center (GC) are crucial for humoral immune responses with high affinity Abs against infectious agents. The follicular dendritic cell (FDC) is known as a key cellular component of the GC microenvironment for GC-B cell survival and proliferation. In this study, we report that IL-15 is produced by human FDC in vivo and by an FDC cell line, FDC/HK cells, in vitro. IL-15 is captured by IL-15Ralpha on the surface of FDC/HK cells. The surface IL-15 is functionally active and augments GC-B cell proliferation. Because GC-B cells have the signal-transducing components (IL-2/15Rbetagamma), but not a receptor for binding of soluble IL-15 (IL-15Ralpha), IL-15 signaling is possibly transduced by transpresentation from FDCs to GC-B cells via cell-cell contact. Together, these results suggest that IL-15 from FDC, in membrane-bound form, plays an important role in supporting GC-B cell proliferation, proposing a new target for immune modulation as well as treatment of B cell tumors of GC origin.
Authors:
Chan-Sik Park; Sun-Ok Yoon; Richard J Armitage; Yong Sung Choi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  173     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-01-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6676-83     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of Cellular Immunology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / biosynthesis*,  metabolism,  physiology*
Apoptosis / immunology
B-Lymphocyte Subsets / cytology*,  immunology,  metabolism
Cell Communication / immunology
Cell Membrane / immunology,  metabolism
Cell Proliferation
Cells, Cultured
Coculture Techniques
Dendritic Cells, Follicular / immunology*,  metabolism*
Germinal Center / cytology*,  immunology,  metabolism
Humans
Interleukin-15 / biosynthesis*,  metabolism,  physiology*
Protein Binding / immunology
Receptors, Interleukin-15
Receptors, Interleukin-2 / metabolism,  physiology
Signal Transduction / immunology
Tumor Necrosis Factor-alpha / pharmacology
Grant Support
ID/Acronym/Agency:
CA092126/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/IL15RA protein, human; 0/Interleukin-15; 0/Receptors, Interleukin-15; 0/Receptors, Interleukin-2; 0/Tumor Necrosis Factor-alpha

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