Document Detail

Follicular dendritic cells in bone marrow lymphoproliferative diseases: an immunohistochemical study including a new paraffin-resistant monoclonal antibody, DR53.
MedLine Citation:
PMID:  8732343     Owner:  NLM     Status:  MEDLINE    
Two-hundred and twenty-one bone marrow biopsies with lymphoid infiltrates were studied histologically and immunohistochemically, to assess the incidence and the pattern of follicular dendritic cells. Three monoclonal antibodies selective for follicular dendritic cells were used: CD21, CD35 and DR53, all reactive on paraffin-embedded material. Follicular dendritic cells were present in two of 38 benign lymphoid aggregates, 92 of 134 low grade B-cell lymphomas (45 of 62 lymphocytic, 16 of 27 lymphoplasmacytoid, 0 of six hairy cell leukaemias, five of six centrocytic, 19 of 21 centroblastic-centrocytic, seven of 12 low grade NOS), one of 23 high grade B-cell lymphomas, 0 of 10 T-cell lymphomas, 0 of three Hodgkin's disease and four of 13 suspicious infiltrates. Follicular dendritic cells were found in lymphomatous involvement with nodular, patchy and massive growth pattern, but not in interstitial ones. They formed follicle-like networks, whose number and size were directly correlated to the tumour mass. The origin and frequency distribution of follicular dendritic cells in bone marrow biopsy lymphomas is discussed and the diagnostic relevance of follicular dendritic cell immunostaining in routine bone marrow biopsy lymphoid infiltrates is assessed.
C Meugé-Moraw; F Delacretaz; A S Baur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histopathology     Volume:  28     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
Institute for Pathology, University of Lausanne, Switzerland.
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MeSH Terms
Aged, 80 and over
Antibodies, Monoclonal / chemistry*
Bone Marrow Neoplasms / chemistry,  diagnosis,  pathology*
Dendritic Cells / chemistry,  immunology*,  pathology*
Lymphoma, Follicular / chemistry,  diagnosis,  pathology*
Lymphoproliferative Disorders / diagnosis,  metabolism,  pathology*
Middle Aged
Reg. No./Substance:
0/Antibodies, Monoclonal

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