Document Detail


Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas.
MedLine Citation:
PMID:  16872443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extranodal follicular dendritic cell (FDC) tumors are rare. Recognition of the morphological spectrum of FDC tumors is important to clinical diagnosis. Herein is presented a case of pancreatic FDC sarcoma with unusual clinicopathological features. A 64-year-old male patient presented with weight loss, poor appetite, abdominal fullness, mild anemia and mild peripheral eosinophilia. Histologically, the tumor was composed of both epithelioid and spindle cells with abundant intracytoplasmic hyaline globules. These tumor cells were positive for CD21, CD23, CD35, S-100 protein, fascin and clusterin. Both epithelioid and spindle tumor cells independently colonized the liver and formed two tumor nodules 18 months after the initial resection. Notably, the two hepatic metastases additionally acquired patchy expression of human leukocyte antigen-DR. The epithelioid FDC in one of the hepatic lesions transformed into numerous bizarre giant cells, which could easily be confused with a metastatic giant cell carcinoma from the pancreas. FDC tumor should therefore be included in the differential diagnoses when dealing with a giant cell tumor.
Authors:
Shih-Che Shen; Chun-Chieh Wu; Kwai-Fong Ng; Ren-Chin Wu; Han-Ming Chen; Tse-Ching Chen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology international     Volume:  56     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-28     Completed Date:  2006-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  466-70     Citation Subset:  IM    
Affiliation:
Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Kwei-Shan, Tao-Yuan, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Giant Cell / pathology*
Dendritic Cells, Follicular / chemistry,  pathology*
Diagnosis, Differential
HLA-DR Antigens / analysis
Humans
Immunohistochemistry
Liver Neoplasms / chemistry,  secondary,  surgery
Male
Middle Aged
Pancreatic Neoplasms / chemistry,  pathology*,  surgery
Sarcoma / chemistry,  pathology*,  surgery
Tumor Markers, Biological / analysis
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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