| Follicular assembly: mechanisms of action. | |
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MedLine Citation:
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PMID: 22065859 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The differentiation of primordial germ cells into functional oocytes is important for the continuation of species. In mammals, primordial germ cells begin to differentiate into oocytes during embryonic development. Oocytes develop in clusters called germline cysts. During fetal or neonatal development, germ cell cysts break apart into single oocytes that become surrounded by pre-granulosa cells to form primordial follicles. During the process of cyst breakdown, a subset of cells in each cyst die with only a third of the initial number of oocytes surviving to form primordial follicles. The mechanisms that control cyst breakdown, oocyte survival and follicle assembly are currently under study. This review describes mechanisms that have been implicated in the control of primordial follicle formation which include programmed cell death regulation, growth factor and other signaling pathways, regulation by transcription factors and hormones, meiotic progression, and changes in cell adhesion. Elucidation of mechanisms leading to formation of the primordial follicle pool will help research efforts in ovarian biology and improve treatments of female infertility, premature ovarian failure and reproductive cancers. |
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Authors:
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Melissa E Pepling |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: - ISSN: 1741-7899 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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M Pepling, Biology, Syracruse University, Syracuse, 13244, United States. |
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