| Follicular Thyroid Carcinoma Arising after Hematopoietic Stem Cell Transplantation in a Child with Pleuropulmonary Blastoma. | |
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MedLine Citation:
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PMID: 22356448 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Pleuropulmonary blastoma (PPB) is a rare and aggressive intrathoracic neoplasm and is associated with other dysplastic or neoplastic conditions. The prognosis, especially of type II (cystic and solid) and type III (solid) PPB, is poor. High-dose chemotherapy (HDC) and hematopoietic stem cell transplantation (HSCT) have been attempted to improve survival rates. We report the development of follicular thyroid carcinoma in a girl who was treated at a young age for PPB. Summary: A 23-month-old girl was evaluated for a clinical diagnosis of pneumonia and found to have a mass in the left lung which grew rapidly. It was removed and diagnosed as a PPB. At age two, she was referred to our hospital for further treatment. She received an adjuvant chemotherapy over six months but developed a recurred mass in her back at age 4.3 years. After removal of mass, she was given a salvage chmotherapy followed by HDC and HSCT but not radiation treatment between 4.4 and 4.9 years of age. At the age of seven, after two years without treatment she presented with multiple thyroid nodules in both lobes that steadily grew over the next two years. At age nine, she underwent total thyroidectomy, which revealed invasive follicular carcinoma. She has remained without clinical evidence of thyroid cancer for one year since surgery. Radiation therapy was not administered because of concerns of causing another malignancy. A literature search combined with the present case indicated that, of the five living patients who were treated with HDC and HSCT, three developed follicular thyroid carcinoma. Conclusions: The high prevalence (3/5, 60%) of follicular thyroid carcinoma in patients with PPB who were treated with HDC and HSCT is striking, suggesting that in patients with PPB either HDC or HSCT contribute to the development of thyroid cancer. Clinicians should be advised of the high risk of thyroid carcinoma occurrence when HDC and HSCT are being contemplated in children with PPB. |
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Authors:
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Seung Han Shin; Jong-Hyung Yoon; Meong Hi Son; Su-Jin Kim; Seog-Yun Park; Hyun Young Kim; Hyung-Sung Lee; Hyeon Jin Park; Byung-Kiu Park |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-22 |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: - ISSN: 1557-9077 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Goyang-si, Korea, Republic of; revival421@empal.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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