| Follicle-stimulating hormone is required for quantitatively normal inhibin secretion in men. | |
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MedLine Citation:
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PMID: 3142919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibin is a glycoprotein hormone produced by the testis and ovary which is postulated to be an important regulator of pituitary FSH secretion. Animal data indicate that inhibin is produced by the Sertoli cells of the testis under the influence of FSH. To determine the role of FSH withdrawal and replacement in the control of inhibin secretion in man, we measured serum inhibin concentrations in men in whom isolated FSH deficiency had been produced by chronic hCG administration; this was followed by FSH replacement. After a 3-month control period, four normal men received hCG for 7 months, resulting in suppression of serum FSH to undetectable levels and urinary FSH excretion to prepubertal levels. Their mean serum inhibin levels fell to 70% of control values during hCG administration [362 +/- 60 (+/- SE) vs. 518 +/- 56 U/L; P less than 0.01]. While continuing hCG, testosterone enanthate was administered for a further 6 months. Serum FSH and inhibin levels remained suppressed to a similar degree. Testosterone administration then was ceased, and hCG continued for a further 2-4 months. Then, while continuing hCG administration, FSH was replaced as either highly purified human FSH (n = 2) or human menopausal gonadotropin (n = 2) for a period of 4-10 months. Serum FSH levels increased to the mid- and upper normal male ranges, respectively. FSH replacement restored serum inhibin levels to 522 +/- 56 U/L (P = NS vs. control). In summary, prolonged selective FSH deficiency induced by chronic hCG administration suppressed inhibin secretion. Replacement of FSH activity restored inhibin secretion to control values. We conclude that 1) FSH is not absolutely required for inhibin secretion in men; and 2) the maintenance of quantitatively normal inhibin secretion requires the combined action of both gonadotropins. |
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Authors:
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R I McLachlan; A M Matsumoto; H G Burger; D M de Kretser; W J Bremner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 67 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-03 Completed Date: 1989-01-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1305-8 Citation Subset: AIM; IM |
Affiliation:
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Gerontology Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, Washington 98108. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / pharmacology Drug Interactions Follicle Stimulating Hormone / deficiency, pharmacology, physiology* Humans Inhibins / blood, secretion* Male Sperm Count / drug effects Testosterone / analogs & derivatives, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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P50-HD-12629/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 315-37-7/testosterone enanthate; 57285-09-3/Inhibins; 58-22-0/Testosterone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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