Document Detail


Follicle-stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET.
MedLine Citation:
PMID:  16871362     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to investigate the association between FSH receptor (FSHR) gene polymorphism at position 680 and the outcomes of controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer (IVF-ET) in Korean women. Two hundred and sixty-three patients under 40 years of age who underwent IVF-ET procedures were included in this study. Patients with polycystic ovary syndrome, endometriosis, or a previous history of ovarian surgery were excluded. Following extraction of genomic DNA, the FSHR polymorphism at position 680 was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. The FSHR genotype distribution was 41.8% for Asn/Asn, 45.6% for Asn/Ser, and 12.5% for Ser/Ser FSHR genotype groups. Although there was no difference among the three genotype groups in terms of the age and infertility diagnosis of study subjects, the basal levels of FSH (day 3) were significantly different [5.7 +/- 0.3 IU/l (mean+/-SEM), 6.0 +/- 0.3 IU/l, and 8.2 +/- 0.9 IU/l for Asn/Asn, Asn/Ser, and Ser/Ser groups, respectively. The Ser/Ser group tended to require a higher dose of gonadotropins for COH, and tended to show lower serum estradiol levels at the time of hCG administration than the other two groups, though these differences did not reach statistical significance. The numbers of oocytes retrieved tended to be different for the three groups (9.6 +/- 0.6, 10.2 +/- 0.6, and 7.9 +/- 0.8 for Asn/Asn, Asn/Ser, and Ser/Ser groups, respectively). Clinical pregnancy rate was significantly higher in Asn/Asn, compared to the others (45.7 vs. 30.5%, P=0.013). The homozygous Ser/Ser genotype of FSHR polymorphism at position 680 may be associated with a reduced ovarian response to COH for IVF-ET, while Asn/Asn genotypes showed a higher pregnancy rate.
Authors:
Jong Kwan Jun; Ji Sung Yoon; Seung-Yup Ku; Young Min Choi; Kyu Ri Hwang; Seo Young Park; Gyoung Hoon Lee; Won Don Lee; Seok Hyun Kim; Jung Gu Kim; Shin Yong Moon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-27
Journal Detail:
Title:  Journal of human genetics     Volume:  51     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-30     Completed Date:  2006-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  665-70     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110-744, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Embryo Transfer*
Female
Fertilization in Vitro / methods*
Genotype
Humans
Infertility, Female
Ovarian Hyperstimulation Syndrome / chemically induced*
Ovary / physiology*
Polymorphism, Genetic / genetics*
Receptors, FSH / genetics*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Receptors, FSH

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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