Document Detail


Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause.
MedLine Citation:
PMID:  18178196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate whether single nucleotide FSH receptor and DAZL gene polymorphisms are associated with menarche and menopause timing. DESIGN: Prospective study. SETTING: Siena and Münster Universities. PATIENT(S): Physiologically menopausal women. INTERVENTION(S): The presence of FSH receptor or DAZL gene polymorphisms was investigated. Blood samples were collected and polymorphisms evaluated in extracted genomic DNA. MAIN OUTCOME MEASURE(S): Menarche age, menopausal age, and total years of fertility were evaluated on the basis of FSH receptor (genotypes Asn/Asn, Asn/Ser, and Ser/Ser at codon 680) and DAZL gene. RESULT(S): The median age of menarche was 13 years in the Asn/Asn group and 12 years in the Asn/Ser and Ser/Ser groups. The median age at menopause was 50 years in the Asn/Asn and Asn/Ser groups and 51 years in the Ser/Ser group. The length of the fertile period was 37 years in the Asn/Asn group, 38 years in the Asn/Ser group, and 39 years in the Ser/Ser group. Regarding the DAZL polymorphism, A/A, A/G, and G/G had the same age at menarche, age at menopause, and length of fertile period. CONCLUSION(S): We found that genotype of FSH receptor or SNP of DAZL do not predict the age at natural menopause and duration of fertility in women. The presence of Asn680/Asn680 genotype is associated with a slightly delayed age at menarche.
Authors:
Irene Zerbetto; Jörg Gromoll; Stefano Luisi; Fernando M Reis; Eberhard Nieschlag; Manuela Simoni; Felice Petraglia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-07
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2008-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2264-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetrics and Gynecology, University of Siena, Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Child
Female
Fertility / genetics
Genotype
Humans
Menarche / genetics
Menopause / genetics*
Middle Aged
Polymorphism, Single Nucleotide*
Prospective Studies
RNA-Binding Proteins / genetics*
Receptors, FSH / genetics*
Chemical
Reg. No./Substance:
0/DAZL protein, human; 0/RNA-Binding Proteins; 0/Receptors, FSH

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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