| Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause. | |
| | |
MedLine Citation:
|
PMID: 18178196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate whether single nucleotide FSH receptor and DAZL gene polymorphisms are associated with menarche and menopause timing. DESIGN: Prospective study. SETTING: Siena and Münster Universities. PATIENT(S): Physiologically menopausal women. INTERVENTION(S): The presence of FSH receptor or DAZL gene polymorphisms was investigated. Blood samples were collected and polymorphisms evaluated in extracted genomic DNA. MAIN OUTCOME MEASURE(S): Menarche age, menopausal age, and total years of fertility were evaluated on the basis of FSH receptor (genotypes Asn/Asn, Asn/Ser, and Ser/Ser at codon 680) and DAZL gene. RESULT(S): The median age of menarche was 13 years in the Asn/Asn group and 12 years in the Asn/Ser and Ser/Ser groups. The median age at menopause was 50 years in the Asn/Asn and Asn/Ser groups and 51 years in the Ser/Ser group. The length of the fertile period was 37 years in the Asn/Asn group, 38 years in the Asn/Ser group, and 39 years in the Ser/Ser group. Regarding the DAZL polymorphism, A/A, A/G, and G/G had the same age at menarche, age at menopause, and length of fertile period. CONCLUSION(S): We found that genotype of FSH receptor or SNP of DAZL do not predict the age at natural menopause and duration of fertility in women. The presence of Asn680/Asn680 genotype is associated with a slightly delayed age at menarche. |
| | |
Authors:
|
Irene Zerbetto; Jörg Gromoll; Stefano Luisi; Fernando M Reis; Eberhard Nieschlag; Manuela Simoni; Felice Petraglia |
Related Documents
:
|
17158326 - U-pb isotopic age of the stw 573 hominid from sterkfontein, south africa. 23430376 - Neighborhood psychosocial hazards and binge drinking among late middle-aged adults. 1509816 - Age at menarche and associated nutritional status variables in karimui and daribi censu... 19023736 - Age at menarche in portuguese rural women from oleiros. 17852286 - Reliability of four scales on balance disorders in persons with multiple sclerosis. 9293196 - Aging and intellectual ability in young, middle-aged, and older educated adults: prelim... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-07 |
Journal Detail:
|
Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-01 Completed Date: 2008-12-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
|
Languages: eng Pagination: 2264-8 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetrics and Gynecology, University of Siena, Siena, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Factors Aged Aged, 80 and over Child Female Fertility / genetics Genotype Humans Menarche / genetics Menopause / genetics* Middle Aged Polymorphism, Single Nucleotide* Prospective Studies RNA-Binding Proteins / genetics* Receptors, FSH / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/DAZL protein, human; 0/RNA-Binding Proteins; 0/Receptors, FSH |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Abdominal scar characteristics as a predictor of intra-abdominal adhesions at repeat cesarean delive...
Next Document: GnRH agonist versus GnRH antagonist in ovarian stimulation: the role of endometrial receptivity.