Document Detail

Follicle-stimulating hormone induces deoxyribonucleic acid polymerase alpha before deoxyribonucleic acid synthesis in immature rat ovarian follicles perfused in vitro.
MedLine Citation:
PMID:  3126468     Owner:  NLM     Status:  MEDLINE    
To examine the effects of follicle-stimulating hormone (FSH) on cell proliferation and cell division in ovaries, deoxyribonucleic acid (DNA) polymerase activities and DNA concentrations were determined in ovarian follicles of immature, hypophysectomized, estradiol-treated rats perfused in vitro. Ovine FSH (2-20 micrograms/mL) significantly enhanced the DNA polymerase alpha activity in the follicles perfused for 180-300 minutes, whereas the DNA polymerase beta activity and DNA concentration showed no significant changes. It is concluded that FSH causes the induction of DNA polymerase alpha before DNA synthesis during follicle growth in immature rat ovaries.
S Usuki; Y Usuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  71     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-15     Completed Date:  1988-04-15     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-10     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
DNA / biosynthesis*
DNA Polymerase II / metabolism*
Enzyme Induction
Follicle Stimulating Hormone / pharmacology*
Ovarian Follicle / enzymology,  metabolism*
Rats, Inbred Strains
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone; 9007-49-2/DNA; EC 2.7.7.-/DNA Polymerase II

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