Document Detail


Follicle-stimulating hormone and estrogen elevate deoxyribonucleic acid alpha-nucleotidyltransferase activity in relationship to deoxyribonucleic acid synthesis in immature rat ovaries.
MedLine Citation:
PMID:  3090885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The deoxyribonucleic acid polymerase activities and deoxyribonucleic acid contents of ovaries were measured to clarify the relationship between hormone-stimulated cell proliferation and the enzymes in ovaries of immature intact rats (4 to 29 days after birth) and hypophysectomized rats. The specific activity of deoxyribonucleic acid alpha-nucleotidyltransferase (the activity per microgram of deoxyribonucleic acid of the ovaries) drastically increased with an increase in the deoxyribonucleic acid content of the ovaries from 4 to 14 days after birth and then remained constant or slightly decreased after the increase, while the activity decreased gradually after hypophysectomy with no increase in the DNA content. Ovine follicle-stimulating hormone or estradiol-17 beta enhanced the deoxyribonucleic acid synthesis and alpha-nucleotidyltransferase activity in the ovaries of hypophysectomized rats, while deoxyribonucleic acid beta-nucleotidyltransferase activity showed no significant change. Ovine luteinizing hormone, progesterone, and testosterone caused no significant increases. These results suggest that follicle-stimulating hormone or estrogen causes the induction of deoxyribonucleic acid alpha-nucleotidyltransferase accompanied by deoxyribonucleic acid synthesis in cell proliferation in immature rat ovaries.
Authors:
S Usuki; M Shioda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  155     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA / biosynthesis*
DNA Polymerase I / biosynthesis
DNA Polymerase II / biosynthesis*
Enzyme Induction / drug effects
Estrogens / pharmacology*
Female
Follicle Stimulating Hormone / pharmacology*
Ovary / enzymology*,  growth & development,  metabolism
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Estrogens; 9002-68-0/Follicle Stimulating Hormone; 9007-49-2/DNA; EC 2.7.7.-/DNA Polymerase I; EC 2.7.7.-/DNA Polymerase II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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