| Follicle-stimulating hormone and estrogen elevate deoxyribonucleic acid alpha-nucleotidyltransferase activity in relationship to deoxyribonucleic acid synthesis in immature rat ovaries. | |
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MedLine Citation:
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PMID: 3090885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The deoxyribonucleic acid polymerase activities and deoxyribonucleic acid contents of ovaries were measured to clarify the relationship between hormone-stimulated cell proliferation and the enzymes in ovaries of immature intact rats (4 to 29 days after birth) and hypophysectomized rats. The specific activity of deoxyribonucleic acid alpha-nucleotidyltransferase (the activity per microgram of deoxyribonucleic acid of the ovaries) drastically increased with an increase in the deoxyribonucleic acid content of the ovaries from 4 to 14 days after birth and then remained constant or slightly decreased after the increase, while the activity decreased gradually after hypophysectomy with no increase in the DNA content. Ovine follicle-stimulating hormone or estradiol-17 beta enhanced the deoxyribonucleic acid synthesis and alpha-nucleotidyltransferase activity in the ovaries of hypophysectomized rats, while deoxyribonucleic acid beta-nucleotidyltransferase activity showed no significant change. Ovine luteinizing hormone, progesterone, and testosterone caused no significant increases. These results suggest that follicle-stimulating hormone or estrogen causes the induction of deoxyribonucleic acid alpha-nucleotidyltransferase accompanied by deoxyribonucleic acid synthesis in cell proliferation in immature rat ovaries. |
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Authors:
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S Usuki; M Shioda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 155 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 447-51 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA / biosynthesis* DNA Polymerase I / biosynthesis DNA Polymerase II / biosynthesis* Enzyme Induction / drug effects Estrogens / pharmacology* Female Follicle Stimulating Hormone / pharmacology* Ovary / enzymology*, growth & development, metabolism Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 9002-68-0/Follicle Stimulating Hormone; 9007-49-2/DNA; EC 2.7.7.-/DNA Polymerase I; EC 2.7.7.-/DNA Polymerase II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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