Document Detail

Folinic acid-responsive seizures initially responsive to pyridoxine.
MedLine Citation:
PMID:  16458834     Owner:  NLM     Status:  MEDLINE    
This report presents a male who developed clonic seizures on the day he was born. The next day, the diagnosis of pyridoxine-dependent seizures was made. However, contradictory to this diagnosis, seizures reappeared despite treatment with pyridoxine. Seizures ceased after folinic acid was initiated. The clinical and biochemical characteristics of folinic acid-responsive seizures are reviewed. Treatment with folinic acid should be considered in neonatal seizures of unknown origin that do not respond to pyridoxine, or manifest a transient response to pyridoxine.
Joost Nicolai; Vivianne H J M van Kranen-Mastenbroek; Ron A Wevers; Wilfred A P T Hurkx; Johan S H Vles
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  34     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-05-18     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-7     Citation Subset:  IM    
Department of Neurology University Hospital Maastricht, Maastricht, The Netherlands.
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MeSH Terms
Epilepsy / cerebrospinal fluid,  drug therapy*,  etiology
Infant, Newborn
Leucovorin / cerebrospinal fluid,  therapeutic use*
Metabolism, Inborn Errors / complications
Pyridoxine / therapeutic use*
Treatment Outcome
Vitamin B Complex / therapeutic use*
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 58-05-9/Leucovorin; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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