Document Detail

Folinic acid in the treatment of human male infertility.
MedLine Citation:
PMID:  8405528     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the clinical and histologic effects of folinic acid in the treatment of round cell idiopathic syndrome. DESIGN: Sixty-five males of infertile couples have been treated with folinic acid alone (15 mg one time per day) for a 3-month period. Various sperm parameters (spermatozoa number and motility, round cell number) have been evaluated before and after the therapy. Moreover, to investigate the histologic patterns of the testis induced by the administration of folinic acid, an experimental animal model has been designed on rats previously treated with chemotherapy drugs. RESULTS: All the investigated human seminal parameters presented significant variations after the treatment. An improvement in spermatozoa number and motility and a decrease in round cell number have constantly been noticed; the significance of the changes was particularly impressive in those men whose partners became pregnant later on. A consistent improvement in the histologic structure of the rat tubular epithelium was also detected. CONCLUSION: Folinic acid appears to be a valuable approach for the treatment of round cell idiopathic syndrome.
G Bentivoglio; F Melica; P Cristoforoni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  60     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-15     Completed Date:  1993-11-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  698-701     Citation Subset:  IM    
Istituto di Clinica Ostetrica e Ginecologica, Università di Genova, Italy.
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MeSH Terms
Cyclophosphamide / pharmacology
Infertility, Male / drug therapy*,  pathology
Leucovorin / therapeutic use*
Methotrexate / pharmacology
Middle Aged
Rats, Wistar
Semen / cytology,  drug effects
Sperm Count / drug effects
Sperm Motility / drug effects
Spermatozoa / drug effects
Statistics as Topic
Testis / drug effects,  pathology
Reg. No./Substance:
50-18-0/Cyclophosphamide; 58-05-9/Leucovorin; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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