| Folic acid, vitamin B12, and homocysteine levels during fasting and after methionine load in patients with Type 1 diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 19834315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To assess plasma concentrations of folic acid, vitamin B12, and total plasma homocysteine (tHCY) during fasting and after methionine load in young patients with Type 1 diabetes mellitus (T1DM). METHODS: We enrolled 41 young patients with T1DM without any sign of microvascular complications and 123 healthy controls in a 1:3 case-control study. Fasting and post-methionine load (PML) tHCY, folic acid, and vitamin B12 levels were measured in both groups. Data regarding chronological age, metabolic control (assessed by mean values of glycated hemoglobin in the last 12 months) and disease duration were also recorded. RESULTS: Fasting and PML tHCY levels were significantly lower in patients than in controls: 7.3+/-2.7 micromol/l vs 8.3+/-2.5 micromol/l (p=0.01), and 16.7+/-5.8 micromol/l vs 17.3+/-4.3 micromol/l (p=0.01), respectively. No correlation was found between fasting and PML tHCY levels and chronological age, disease duration, metabolic control, and insulin requirement. Patients had significantly higher vitamin B12 levels compared to controls: 767+/-318 pg/ml vs 628+/-236 pg/ml (p=0.003), while folic acid turned out to be lower in patients than in controls: 5.3+/-1.9 nmol/l vs 7.5+/-2.6 nmol/l (p<0.0001). CONCLUSIONS: Adolescents and young adults with T1DM without microvascular complications showed lower tHCY both during fasting and after methionine load. Lower folate concentrations in these patients might benefit from food fortification. |
| | |
Authors:
|
A Giannattasio; M G Calevo; G Minniti; D Gianotti; M Cotellessa; F Napoli; R Lorini; G d'Annunzio |
Related Documents
:
|
17479165 - Efficacy of antioxidant treatment in reducing resistin serum levels: a randomized study. 1978275 - Effects of dapiprazole on the reversal of pharmacologically induced mydriasis. 8815965 - Airways reactivity, atopy and bronchoalveolar lavage in male smokers with airflow obstr... 8029165 - Improvement in glucose tolerance and beta-cell function in a patient with vitamin d def... 7806015 - The role of islet secretory function in the development of diabetes in the gk wistar rat. 10664315 - Mechanism of fat-induced attenuation of glucose-induced insulin secretion from mouse pa... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-15 |
Journal Detail:
|
Title: Journal of endocrinological investigation Volume: 33 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-06-10 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
|
Languages: eng Pagination: 297-9 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Genoa, IRCCS G. Gaslini, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aging / physiology Blood Glucose / metabolism Case-Control Studies Child Diabetes Mellitus, Type 1 / blood* Fasting / metabolism* Female Folic Acid / blood* Homocysteine / blood* Humans Male Methionine / diagnostic use* Sex Characteristics Vitamin B 12 / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 63-68-3/Methionine; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effects of polyphenol containing antioxidants on oxidative stress and lipid peroxidation in type...
Next Document: Thermogenic Response and Leptin Levels Rise After Recovery of the Euthyroid State.