Document Detail

Folic acid supplements and fortification affect the risk for neural tube defects, vascular disease and cancer: evolving science.
MedLine Citation:
PMID:  12771346     Owner:  NLM     Status:  MEDLINE    
Folic acid supplements reduce the risk of neural tube defects and may be associated with reduced risk for vascular disease and cancer. Research data from both observational and controlled intervention studies provide strong support for the existing public health policies related to folic acid and neural tube defects. However, educational efforts to promote daily intake of folic acid supplements by women of reproductive age have not, in most cases, resulted in increased supplement use. In contrast, food fortification appears to be associated with a reduction in neural tube defects in the United States and Canada but is not practiced universally. The potential for folic acid supplements to reduce the incidence and severity of vascular disease and cancer is the focus of major research efforts including ongoing intervention studies.
Lynn B Bailey; Gail C Rampersaud; Gail P A Kauwell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1961S-1968S     Citation Subset:  IM    
Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611-0370, USA.
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MeSH Terms
Dietary Supplements*
Folic Acid / administration & dosage*
Food, Fortified*
Neoplasms / prevention & control*
Neural Tube Defects / prevention & control*
Vascular Diseases / prevention & control*
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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