Document Detail


Folic acid supplements during pregnancy and risk of miscarriage.
MedLine Citation:
PMID:  11564486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although taking supplements that contain 400 microg of folic acid before and during early pregnancy reduces a woman's risk for having a baby with a neural-tube defect (NTD), the effects of such supplements on other pregnancy outcomes remain unclear. We examined whether the use of such supplements affects the occurrence of miscarriage. METHODS: Participants were women in China who had taken part in a recent folic acid campaign to prevent NTDs and who had registered in this campaign before they became pregnant for the first time. We examined the risk for miscarriage among women who had confirmed pregnancies and who had or had not taken pills containing only 400 microg of folic acid before and during early pregnancy. RESULTS: The overall rate of miscarriage was 9.1% (2155/23806). The rates of miscarriage among women who had and had not taken folic acid pills before and during the first trimester were 9.0% and 9.3%, respectively (risk ratio 0.97 [95% CI 0.84-1.12]). The distributions of gestational age at pregnancy diagnosis and at miscarriage were similar for both groups of women. INTERPRETATION: In this population-based study of a cohort of women whose use of folic acid supplements while pregnant had been previously documented and who had been pregnant for the first time, we found no evidence that daily consumption of 400 microg of folic acid before and during early pregnancy influenced their risk for miscarriage.
Authors:
J Gindler; Z Li; R J Berry; J Zheng; A Correa; X Sun; L Wong; L Cheng; J D Erickson; Y Wang; Q Tong;
Related Documents :
1856046 - Iron status in nigerian mothers and their newborns.
3017976 - Iron mediates paraquat toxicity in escherichia coli.
19021536 - Iron and copper, and their interactions during development.
14506896 - Changes in haemostasis during normal pregnancy: does homocysteine play a role in mainta...
10846336 - Misoprostol alone--a new method of medical abortion?
23696566 - Maternal obesity has little effect on the immediate offspring but impacts on the next g...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  358     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-20     Completed Date:  2001-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  796-800     Citation Subset:  AIM; IM    
Affiliation:
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / chemically induced*,  epidemiology
Adult
Body Mass Index
China / epidemiology
Cohort Studies
Educational Status
Female
Folic Acid / adverse effects*
Hematinics / adverse effects*
Humans
Population Surveillance*
Pregnancy
Risk Factors
Chemical
Reg. No./Substance:
0/Hematinics; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Efficacy of single-dose SA 14-14-2 vaccine against Japanese encephalitis: a case control study.
Next Document:  Human epilepsy associated with dysfunction of the brain P/Q-type calcium channel.