Document Detail

Folic acid in pregnancy - is there a link with childhood asthma or wheeze?
MedLine Citation:
PMID:  21655492     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Folic acid supplementation has an established role in early pregnancy for preventing neural tube defects. However, there is controversy over a possible link between late pregnancy folic acid supplementation and childhood asthma.
OBJECTIVE: To review the evidence exploring the association between maternal folate exposure in pregnancy and childhood asthma or wheeze.
RESULTS: Four relevant observational studies were identified. Two found statistically significant associations between childhood asthma and late (but not early) pregnancy maternal folic acid exposure. Another found a statistically significant association between childhood wheeze and early (but not late) pregnancy maternal folic acid exposure. A fourth study found little association between maternal dietary folate in pregnancy and infantile wheeze.
DISCUSSION: The currently available evidence regarding an association between folate in pregnancy and childhood asthma or wheeze is conflicting. We offer suggestions for discussing the potential risk with patients and recommend further research on this subject be conducted.
Eleanor Sharland; Brett Montgomery; Raquel Granell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Australian family physician     Volume:  40     ISSN:  0300-8495     ISO Abbreviation:  Aust Fam Physician     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2012-01-05     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0326701     Medline TA:  Aust Fam Physician     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  421-4     Citation Subset:  IM    
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MeSH Terms
Asthma / chemically induced*
Dietary Supplements / adverse effects*
Folic Acid / adverse effects*
Respiratory Sounds*
Vitamin B Complex / adverse effects*
Grant Support
G0902125//Medical Research Council
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 935E97BOY8/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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