| Folic acid in pregnancy - Is there a link with childhood asthma or wheeze? | |
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MedLine Citation:
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PMID: 21655492 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND Folic acid supplementation has an established role in early pregnancy for preventing neural tube defects. However, there is controversy over a possible link between late pregnancy folic acid supplementation and childhood asthma. OBJECTIVE To review the evidence exploring the association between maternal folate exposure in pregnancy and childhood asthma or wheeze. RESULTS Four relevant observational studies were identified. Two found statistically significant associations between childhood asthma and late (but not early) pregnancy maternal folic acid exposure. Another found a statistically significant association between childhood wheeze and early (but not late) pregnancy maternal folic acid exposure. A fourth study found little association between maternal dietary folate in pregnancy and infantile wheeze. DISCUSSION The currently available evidence regarding an association between folate in pregnancy and childhood asthma or wheeze is conflicting. We offer suggestions for discussing the potential risk with patients and recommend further research on this subject be conducted. |
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Authors:
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Eleanor Sharland; Brett David Montgomery; Raquel Granell |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Australian family physician Volume: 40 ISSN: 0300-8495 ISO Abbreviation: Aust Fam Physician Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326701 Medline TA: Aust Fam Physician Country: Australia |
Other Details:
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Languages: eng Pagination: 421-4 Citation Subset: IM |
Affiliation:
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MBBS(Hons), FRACGP, is a former academic registrar, Discipline of General Practice, School of Primary, Aboriginal and Rural Health Care, University of Western Australia, Perth, Western Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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