| Folic acid derivatives do not reproduce the neurotoxic effects of kainic acid on chicken retina. | |
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MedLine Citation:
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PMID: 7162698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methyltetrahydrofolic acid, formyltetrahydrofolic acid, folic acid and dihydrofolic acid were injected intravitreally into the eyes of chickens. No short-term or long-term signs of neurotoxicity were observed, even when doses 100-200 times those at which kainic acid produces clear neurotoxic effects were injected. The folic acid derivatives neither inhibited nor potentiated the neurotoxic effects. Thus no support is given to the suggestion that folic acid and its derivatives may act as kainic acid agonists or antagonists, even though the receptors involved in kainic acid-induced neurotoxicity appear to be of the kainic acid rather than quisqualic acid or N-methyl-D-aspartic acid type. |
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Authors:
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I G Morgan; S El-Lakany |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 34 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 69-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens Choline O-Acetyltransferase / metabolism Dose-Response Relationship, Drug Folic Acid / analogs & derivatives*, toxicity* Formyltetrahydrofolates / toxicity Kainic Acid / toxicity* Pyrrolidines / toxicity* Retina / drug effects* Tetrahydrofolates / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Formyltetrahydrofolates; 0/Pyrrolidines; 0/Tetrahydrofolates; 134-35-0/5-methyltetrahydrofolate; 4033-27-6/dihydrofolate; 487-79-6/Kainic Acid; 59-30-3/Folic Acid; EC 2.3.1.6/Choline O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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