| Folic acid blinded trial in identical twins with fragile X syndrome. | |
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MedLine Citation:
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PMID: 3890529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monozygous twin 14-year-old mentally retarded boys with the fragile X syndrome were treated either with 10 mg folic acid by mouth daily or with a placebo for three test periods of 3-month duration each in a blind study. For each twin, tests of cognitive functioning, reading, spelling, and math skills, and linguistic and perceptual skills were compared. Although there was considerable variation in performance on these tests during the two baseline periods, there were no observable beneficial effects of therapy. The routine use of folic acid in patients with established mental retardation and the fragile X syndrome is not indicated. |
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Authors:
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D S Rosenblatt; E A Duschenes; F V Hellstrom; M S Golick; M J Vekemans; S F Zeesman; E Andermann |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of human genetics Volume: 37 ISSN: 0002-9297 ISO Abbreviation: Am. J. Hum. Genet. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-07-15 Completed Date: 1985-07-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370475 Medline TA: Am J Hum Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 543-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Clinical Trials as Topic Diseases in Twins* Female Folic Acid / blood, therapeutic use* Fragile X Syndrome / drug therapy*, genetics, psychology Humans Intelligence Tests Learning Male Mental Retardation / drug therapy, genetics, psychology Perception Pregnancy Psychometrics Sex Chromosome Aberrations / drug therapy* Twins* Twins, Monozygotic* |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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