Document Detail

Folic acid absorption in women with a history of pregnancy with neural tube defect.
MedLine Citation:
PMID:  7572709     Owner:  NLM     Status:  MEDLINE    
Folic acid absorption was compared in nonpregnant women with a history of pregnancy with a neural tube defect (cases)(n = 10) with that of control women (n = 10) with a normal pregnancy history. [2H4]folic acid was administered in an oral dose (400 micrograms) to fasting case and control subjects after a 30-d saturation protocol involving daily ingestion of two 1-mg folic acid supplements. Serum and red blood cell folate concentrations were not different for case and control subjects before or during the saturation protocol (P > 0.05). The percentage (x +/- SD) of the oral dose of [2H4]folic acid excreted in 24-h urine collections postdose was not different (P > 0.05) for case compared with control subjects (9.05 +/- 2.25% and 11.10 +/- 3.41%, respectively). These data suggest that the absorption of folic acid routinely consumed in supplements and fortified food products is not impaired in women with a history of a pregnancy with a neural tube defect. Further case-controlled studies are needed to compare the absorption of the predominant dietary form of the vitamin.
B A Davis; L B Bailey; J F Gregory; J P Toth; J Dean; R E Stevenson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  62     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-20     Completed Date:  1995-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  782-4     Citation Subset:  AIM; IM    
Food Science and Human Nutrition Department, University of Florida, Gainesville 32611, USA.
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MeSH Terms
Administration, Oral
Biological Availability
Case-Control Studies
Folic Acid / blood,  pharmacokinetics*,  urine
Intestinal Absorption
Neural Tube Defects*
Pregnancy Complications / metabolism*
Grant Support
U85/CCU408774-01//PHS HHS
Reg. No./Substance:
59-30-3/Folic Acid
Comment In:
Am J Clin Nutr. 1996 Jun;63(6):976-7   [PMID:  8644695 ]

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