| Folic acid absorption in women with a history of pregnancy with neural tube defect. | |
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MedLine Citation:
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PMID: 7572709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Folic acid absorption was compared in nonpregnant women with a history of pregnancy with a neural tube defect (cases)(n = 10) with that of control women (n = 10) with a normal pregnancy history. [2H4]folic acid was administered in an oral dose (400 micrograms) to fasting case and control subjects after a 30-d saturation protocol involving daily ingestion of two 1-mg folic acid supplements. Serum and red blood cell folate concentrations were not different for case and control subjects before or during the saturation protocol (P > 0.05). The percentage (x +/- SD) of the oral dose of [2H4]folic acid excreted in 24-h urine collections postdose was not different (P > 0.05) for case compared with control subjects (9.05 +/- 2.25% and 11.10 +/- 3.41%, respectively). These data suggest that the absorption of folic acid routinely consumed in supplements and fortified food products is not impaired in women with a history of a pregnancy with a neural tube defect. Further case-controlled studies are needed to compare the absorption of the predominant dietary form of the vitamin. |
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Authors:
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B A Davis; L B Bailey; J F Gregory; J P Toth; J Dean; R E Stevenson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 62 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-11-20 Completed Date: 1995-11-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 782-4 Citation Subset: AIM; IM |
Affiliation:
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Food Science and Human Nutrition Department, University of Florida, Gainesville 32611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Biological Availability Case-Control Studies Female Folic Acid / blood, pharmacokinetics*, urine Humans Intestinal Absorption Neural Tube Defects* Pregnancy Pregnancy Complications / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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U85/CCU408774-01//PHS HHS |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 1996 Jun;63(6):976-7
[PMID:
8644695
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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