Document Detail

Folic acid and Vitamin B6 supplementation and plasma homocysteine concentrations in healthy young women.
MedLine Citation:
PMID:  9565824     Owner:  NLM     Status:  MEDLINE    
Elevated plasma homocysteine levels are a risk factor for atherosclerotic disease. Elevated fasting plasma homocysteine concentrations can be reduced by vitamin supplementation with folic acid, vitamin B6 and vitamin B12, but the effect of nutritive amounts of single vitamins on homocysteine plasma levels within the normal range is not known. This study was performed to investigate the effect of folic acid supplementation (400 micrograms/d) on fasting plasma homocysteine levels in healthy young women, in comparison to vitamin B6 (2 mg/d) or a combination of both vitamins. Healthy young women with normal homocysteine levels were supplemented for four weeks either with folic acid, vitamin B6 or the combination. The combination of folic acid and vitamin B6 reduced plasma homocysteine by 17%. Supplementation with folic acid reduced plasma homocysteine levels by 11.5%. The effect of folic acid and vitamin B6 was not significantly different from the effect of folic acid alone. Vitamin B6 had no effect on plasma homocysteine concentrations. Results show that homocysteine levels within the normal range are lowered by low-dose vitamin supplementation including folic acid.
J Dierkes; M Kroesen; K Pietrzik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  68     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1998  
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Dept. of Pathophysiology of Human Nutrition, University of Bonn., Germany.
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MeSH Terms
Arteriosclerosis / blood
Drug Interactions
Folic Acid / administration & dosage*,  blood
Homocysteine / blood*
Pyridoxal Phosphate / blood
Pyridoxine / administration & dosage*,  blood
Reference Values
Risk Factors
Reg. No./Substance:
454-28-4/Homocysteine; 54-47-7/Pyridoxal Phosphate; 59-30-3/Folic Acid; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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