| Folic acid supplementation improves vascular function in professional dancers with endothelial dysfunction. | |
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MedLine Citation:
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PMID: 21715240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine if folic acid supplementation improves vascular function (brachial artery flow-mediated dilation [FMD]) in professional dancers with known endothelial dysfunction. DESIGN: Prospective cross-sectional study. SETTING: Academic institution in the Midwestern United States. SUBJECTS: Twenty-two professional ballet dancers volunteered for this study. MAIN OUTCOME MEASURES: Subjects completed a 3-day food record to determine caloric and micronutrient intake. Menstrual status was determined by interview and questionnaire. Endothelial function was determined as flow-induced vasodilation measured by high-frequency ultrasound of the brachial artery. A change in brachial diameter of <5% to hyperemic flow stimulus was defined a priori as endothelial dysfunction. Subjects with abnormal FMD took 10 mg of folic acid daily for 4 weeks, and FMD testing was then repeated. Serum whole blood was measured for folic acid levels before and after supplementation. RESULTS: Sixty-four percent of dancers (n = 14) had abnormal brachial artery FMD (<5%) (mean ± standard deviation, 2.9% ± 1.5%). After 4 weeks of folic acid supplementation (10 mg/day), FMD improved in all the subjects (7.1% ± 2.3%; P < .0001). CONCLUSIONS: This study reveals that vascular endothelial function improves in dancers after supplementation with folic acid (10 mg/day) for at least 4 weeks. This finding may have clinically important implications for future cardiovascular disease risk prevention. |
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Authors:
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Anne Z Hoch; Paula Papanek; Aniko Szabo; Michael E Widlansky; David D Gutterman |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-06-29 |
Journal Detail:
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Title: PM & R : the journal of injury, function, and rehabilitation Volume: 3 ISSN: 1934-1563 ISO Abbreviation: PM R Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-23 Completed Date: 2012-04-03 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 101491319 Medline TA: PM R Country: United States |
Other Details:
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Languages: eng Pagination: 1005-12 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Orthopaedic Surgery/Cardiovascular Center, Medical College of Wisconsin, Milwaukee, USA. azeni@mcw.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brachial Artery / drug effects, physiopathology* Cross-Sectional Studies Dancing* Dietary Supplements* Endothelium, Vascular / drug effects, physiopathology* Female Folic Acid / administration & dosage*, pharmacokinetics Humans Prognosis Prospective Studies Questionnaires Vascular Diseases / blood, physiopathology, prevention & control* Vasodilation / drug effects Vitamin B Complex / administration & dosage*, pharmacokinetics Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1UL1RR031973/RR/NCRR NIH HHS; 5-M01-RR00058-39/RR/NCRR NIH HHS; M01 RR000058-39/RR/NCRR NIH HHS; UL1 RR031973-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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