Document Detail


Folic acid supplementation improves vascular function in professional dancers with endothelial dysfunction.
MedLine Citation:
PMID:  21715240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if folic acid supplementation improves vascular function (brachial artery flow-mediated dilation [FMD]) in professional dancers with known endothelial dysfunction.
DESIGN: Prospective cross-sectional study.
SETTING: Academic institution in the Midwestern United States.
SUBJECTS: Twenty-two professional ballet dancers volunteered for this study.
MAIN OUTCOME MEASURES: Subjects completed a 3-day food record to determine caloric and micronutrient intake. Menstrual status was determined by interview and questionnaire. Endothelial function was determined as flow-induced vasodilation measured by high-frequency ultrasound of the brachial artery. A change in brachial diameter of <5% to hyperemic flow stimulus was defined a priori as endothelial dysfunction. Subjects with abnormal FMD took 10 mg of folic acid daily for 4 weeks, and FMD testing was then repeated. Serum whole blood was measured for folic acid levels before and after supplementation.
RESULTS: Sixty-four percent of dancers (n = 14) had abnormal brachial artery FMD (<5%) (mean ± standard deviation, 2.9% ± 1.5%). After 4 weeks of folic acid supplementation (10 mg/day), FMD improved in all the subjects (7.1% ± 2.3%; P < .0001).
CONCLUSIONS: This study reveals that vascular endothelial function improves in dancers after supplementation with folic acid (10 mg/day) for at least 4 weeks. This finding may have clinically important implications for future cardiovascular disease risk prevention.
Authors:
Anne Z Hoch; Paula Papanek; Aniko Szabo; Michael E Widlansky; David D Gutterman
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-29
Journal Detail:
Title:  PM & R : the journal of injury, function, and rehabilitation     Volume:  3     ISSN:  1934-1563     ISO Abbreviation:  PM R     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-23     Completed Date:  2012-04-03     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101491319     Medline TA:  PM R     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1005-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Orthopaedic Surgery/Cardiovascular Center, Medical College of Wisconsin, Milwaukee, USA. azeni@mcw.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brachial Artery / drug effects,  physiopathology*
Cross-Sectional Studies
Dancing*
Dietary Supplements*
Endothelium, Vascular / drug effects,  physiopathology*
Female
Folic Acid / administration & dosage*,  pharmacokinetics
Humans
Prognosis
Prospective Studies
Questionnaires
Vascular Diseases / blood,  physiopathology,  prevention & control*
Vasodilation / drug effects
Vitamin B Complex / administration & dosage*,  pharmacokinetics
Young Adult
Grant Support
ID/Acronym/Agency:
1UL1RR031973/RR/NCRR NIH HHS; 5-M01-RR00058-39/RR/NCRR NIH HHS; M01 RR000058-39/RR/NCRR NIH HHS; UL1 RR031973-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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